A4 Study: Testing Solanezumab before Alzheimer’s Symptoms Appear

Healthy older adults with no symptoms of Alzheimer’s disease are the focus of a large study involving 61 medical centers across the U.S., Canada and Australia. The Anti-Amyloid Treatment in Asymptomatic Alzheimer’s study aims to find out if Eli Lilly’s solanezumab, which failed in earlier studies to help people with Alzheimer’s symptoms, will help prevent Alzheimer’s if given long before symptoms appear. Solanezumab...
Source: Carol Bradley Bursack's SharePosts - Category: Dementia Authors: Source Type: blogs

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Publication date: Available online 22 June 2019Source: NeuroImageAuthor(s): Martin Sjøgård, Xavier De Tiège, Alison Mary, Philippe Peigneux, Serge Goldman, Guy Nagels, Jeroen van Schependom, Andrew J. Quinn, Mark Woolrich, Vincent WensAbstractThe default-mode network (DMN) and its principal core hubs in the posterior midline cortices (PMC), i.e., the precuneus and the posterior cingulate cortex, play a critical role in the human brain structural and functional architecture. Because of their centrality, they are affected by a wide spectrum of brain disorders, e.g., Alzheimer's disease. Non-invasive elect...
Source: NeuroImage - Category: Neuroscience Source Type: research
Conclusion: Textures of the hippocampus, precuneus and posterior cingulate cortex predicted conversion from MCI to Alzheimer disease at an earlier time point and with higher accuracy than hippocampal volume. PMID: 31228173 [PubMed - as supplied by publisher]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research
Authors: Leng Y, Redline S, Stone KL, Ancoli-Israel S, Yaffe K Abstract INTRODUCTION: Little is known about the longitudinal association between napping and cognitive impairment in older adults. METHODS: We used wrist actigraphy to measure naps in 2751 community-dwelling older men. Cognition was assessed repeatedly over 12 years, and clinically significant cognitive impairment was determined by physician diagnosis, Alzheimer's medication use or a significant cognitive decline. RESULTS: After adjustment for all covariates, men with longer napping duration had greater cognitive decline and higher risk of...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
ng Yang Pinocembrin is one of the most abundant flavonoids in propolis, and it may also be widely found in a variety of plants. In addition to natural extraction, pinocembrin can be obtained by biosynthesis. Biosynthesis efficiency can be improved by a metabolic engineering strategy and a two-phase pH fermentation strategy. Pinocembrin poses an interest for its remarkable pharmacological activities, such as neuroprotection, anti-oxidation, and anti-inflammation. Studies have shown that pinocembrin works excellently in treating ischemic stroke. Pinocembrin can reduce nerve damage in the ischemic area and reduce mitochon...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
AbstractPurpose of reviewThe goal of the current review is to provide an update on the management of agitation in persons with dementia with a focus on pharmacological management of persons with Alzheimer ’s disease.Recent findingsAs consistently effective and safe pharmacologic interventions are still lacking, identifying and addressing medical and environmental precipitants remain a priority. Acetylcholinesterase inhibitors and memantine should be initiated to enhance cognition, and if present, management of insomnia or sundowning with trazodone is indicated. If agitation persists, treatment with citalopram can be ...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
ANAHEIM, CA - Researchers have developed a tau PET radioligand that can accurately...Read more on AuntMinnie.comRelated Reading: MRI measurements can change Parkinson's diagnosis FDG-PET predicts survival in Parkinsonian syndrome SNMMI: Alzheimer's PET tracer wins Image of the Year award FDG-PET distinguishes Parkinson's from other disorders
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Li X, Chu S, Liu Y, Chen N Abstract Rhubarb is a well-known traditional Chinese medicine; it has been used in China for thousands of years. Rhubarb anthraquinones are the major medicinal ingredients derived from rhubarb including emodin, aloe-emodin, chrysophanol, rhein, physcion, and danthron. These different anthraquinone derivatives alone or in combination play a therapeutic role in central nervous system diseases (CNSD), such as cerebral ischemic stroke, intracerebral hemorrhage, traumatic brain injury, brain tumor, Alzheimer's disease, depression, and others. We review the experimental studies on thes...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
New research finds that nilvadipine, a drug doctors commonly use to treat high blood pressure, increases the blood flow to the brain's hippocampus.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
This study examined the effects of electroacupuncture (EA) stimulation on BACE1, APP, and p-PKA protein levels in hippocampal tissue samples. Memory and learning abilities were assessed using the Morris water maze test after EA intervention. Immunofluorescence, immunohistochemistry, and western blot were employed to assess the distribution patterns and expression levels of BACE1, APP, and p-PKA, respectively. The results showed the downregulation of BACE1 and APP and the activation of PKA by EA. In summary, EA treatment might reduce BACE1 deposition in APP/PS1 transgenic mice and regulate PKA and its associated substrates,...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
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