Older donor lungs should be considered for transplantation

(Elsevier) With a scarcity of lungs available for transplantation, the use of lungs from donors older than age 60 has been shown to achieve reasonable outcomes and should be considered as a viable option, according to research published online today in The Annals of Thoracic Surgery.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Tiffany Senter (pictured) of Shasta Lake City, California is only 25, but she's been at deaths door twice. Tiffany was born with cystic fibrosis and has had to have two lung transplants.
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Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research
Sepsis is a dynamic disease, displaying an inflammatory profile that varies over time and for each organ. Controlling the inflammatory response based in targeting a single molecule has been proved useless. We hypothesized that treatment with bone marrow-derived mononuclear cells (BMDMCs) may be more efficient to modulate the systemic inflammatory response to infection. Adult male Balb/c mice were subjected to cecal ligation and puncture (CLP) or endotoxemia model of experimental sepsis. BMDMCs were separated under Ficoll gradient and injected intravenously 1 h after the procedures. Cytokines concentration was quantified in...
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
The objective of our study was to evaluate the impact of CAS on lung function after lung transplantation. MATERIAL AND METHODS All lung transplant recipients from June 2009 to August 2014 in a single center (Strasbourg, France) were retrospectively reviewed. RESULTS A total of 191 lung transplantations were performed: 175 bilateral, 15 single, and 1 heart-lung transplantation. Of the 161 bilateral lung-transplanted patients who survived>3 months, 22 (13.6%) developed CAS requiring endobronchial treatment. All these patients were treated by endoscopic balloon dilatation, and 9 additionally needed endobronchial stents. Re...
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Publication date: Available online 11 February 2019Source: The Annals of Thoracic SurgeryAuthor(s): Charles D. Fraser, Xun Zhou, Joshua C. Grimm, Alejandro Suarez-Pierre, Todd C. Crawford, Cecillia Lui, Errol L. Bush, Narutoshi Hibino, Marshall L. Jacobs, Luca A. Vricella, Christian MerloAbstractBackgroundThe impact of size mismatch between donor and recipient in pediatric lung transplantation (PLTx) is currently unknown. Previous studies in adults have suggested that oversized allografts are associated with improved outcomes following lung transplantation. We investigated this relationship in order to quantify its effect ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
A 50-yearold lady presented to hospital with blurred vision and pyrexia. She had previously undergone a renal transplant and was on standard immunosuppression therapy. In addition, she had recently been treated for invasive pulmonary aspergillosis. On this admission, she was diagnosed with endophthalmitis and a right ankle abscess. She was started on broad spectrum antimicrobials and the ankle collection was drained. She continued to have febrile episodes and a transthoracic echocardiogram revealed an echogenic mass in the left ventricle (Image 1 ░A).
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Source Type: research
This study aimed to establish the safety of anti-fibrotic therapy in the peri-transplant period, particularly with regards to healing of the bronchial anastomosis.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Outflow graft obstruction is a known and described complication following continuous-flow (CF) left ventricular assist device (LVAD) implantation1. Mechanisms include anastomotic stenosis, angulation, twisting, and external impingement from protective outer sleeves2. Although non-interventional strategies may be employed, physiologically important outflow graft obstruction typically requires intervention.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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