CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

Cytotoxic T lymphocytes (CTLs) are important to eliminate virus-infected cells and cancer cells from the body. Ahrends et  al. reveal that CD4+ T cells help CTLs acquire their ability to perform this task through a specific gene program that involves the downregulation of coinhibitory receptors and increased motility and migration capacities.

Source: Immunity - November 7, 2017 Category: Allergy & Immunology Authors: Tomasz Ahrends, Aldo Spanjaard, Bas Pilzecker, Nikolina B ąbała, Astrid Bovens, Yanling Xiao, Heinz Jacobs, Jannie Borst Tags: Article Source Type: research