p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes

In this study, we investigate the activities of p53 under normal low-stress conditions and discover that p53 is capable of maintaining the expression of a group of important tumor suppressor genes at baseline, many of which are haploinsufficient, which could contribute to p53-mediated tumor suppression. Mol Cancer Res; 15(8); 1051–62. ©2017 AACR.

Source: Molecular Cancer Research - August 1, 2017 Category: Cancer & Oncology Authors: Pappas, K., Xu, J., Zairis, S., Resnick-Silverman, L., Abate, F., Steinbach, N., Ozturk, S., Saal, L. H., Su, T., Cheung, P., Schmidt, H., Aaronson, S., Hibshoosh, H., Manfredi, J., Rabadan, R., Parsons, R. Tags: Oncogenes and Tumor Suppressors Source Type: research