SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer

ConclusionsWe have identified a novel mechanism by which P53 was inactivated via SIRT3 in PTEN-deficient cells. This may shed light on the mechanisms underlying the malignancy of PTEN-deficient NSCLC.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research