Jekyll-and-Hyde yeast makes chocolate taste great but also causes opportunistic infections
Jekyll-and-Hyde yeast makes chocolate taste great but also causes opportunistic infectionsTue, 10/31/2017 - 16:43News blog
Condition: Invasive Aspergillosis in Patients With Onco-haematological Diseases Intervention: Diagnostic Test: DNA extraction and detection of Aspergillus fumigatus in serum samples Sponsors: Assistance Publique - Hôpitaux de Paris; Société ADEMTECH SA Not yet recruiting
Conclusion: The IFI incidence and mortality rate were similar to that reported in the literature. The IFI rate was higher in the group using prophylaxis, as this is a high-risk group. Although the IFI rate was not significantly different between groups using prophylaxis, patients should be followed closely for the effective use of posaconazole prophylaxis. PMID: 29151329 [PubMed]
Wed, 11/22/2017 - 11:23News blog
In conclusion, a dysbiotic mycobiome dominated by C. albicans was found in association with OSCC, a finding worth further investigation. PMID: 29152157 [PubMed]
Summary Fungal sensitisation in adults is associated with severe asthma but prevalence and clinical significance of fungal sensitisation remains unclear in paediatric population. The aim of this study was to study the association of fungal sensitisation with disease severity in children with persistent asthma. One hundred children with persistent asthma in age group 7‐15 years, symptom duration>2 years and forced expiratory volume in first second>50% of expected were enrolled. Skin prick test (SPT) to 8 fungal antigens and total serum immunoglobulin E (IgE) were done. Fungal sensitisation was described as...
Conclusion and Clinical RelevanceEosinophils are phenotypically and functionally heterogeneous. As shown here, eosinophils from fungal allergen–challenged wild‐type mice maintain a distinct cytokine profile, and, unlike eosinophils isolated from IL5tg mice, they survive ex vivo in the absence of exogenous pro‐survival cytokine support. As treatments for asthma currently in development focus on limiting eosinophil viability via strategic cytokine blockade, the molecular mechanisms underlying differential survival merit further investigation.
The incidence of tuberculosis (TB) is high among human immunodeficiency virus (HIV) infected Ugandans. Recent evidence suggests that Chronic Pulmonary Aspergillosis and Aspergillus sensitisation might be responsi...
Methyl (3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl)benzoyl)glycinate (1), a new sydonic acid derivative with glycinate, together with sydonic acid (2), sydowic acid (3), and 7-deoxy-7,14-didehydrosydonic acid (4), were isolated from a marine-derived Aspergillus sydowii strain CUGB-F126. Their structures were elucidated by spectroscopic analysis, including high-resolution mass spectroscopy, and 1D and 2D NMR techniques. All of these compounds did not show inhibitory activity against Staphylococcus aureus and Candida albicans.
Publication date: April 2018 Source:Journal of Food Engineering, Volume 222 Author(s): Ehsan Jenab, Mehdi Omidghane, Paolo Mussone, Daniel Hernandez Armada, Jonathan Cartmell, Carlo Montemagno Galacto-oligosaccharides (GOS) synthesized from lactose using Aspergillus oryzae β-galactosidases. We studied the influences of enzyme concentration (0.02–0.1%. w/v), temperature (40–70 °C), pH (4.5–8), lactose concentration (5–40%, w/v) and foam architecture reaction media on formation of GOS. The total GOS increased from about 7 to 23 (wt.% of initial lactose) with an increase in lactose from ...