An explorative analysis of process and formulation variables affecting comilling in a vibrational mill: The case of praziquantel
Publication date: 30 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 2 Author(s): Beatrice Perissutti, Nadia Passerini, Ramona Trastullo, Jennifer Keiser, Debora Zanolla, Guglielmo Zingone, Dario Voinovich, Beatrice Albertini Praziquantel, a BCS II class anthelmintic drug used for the treatment of schistosome infections, was coground in a vibrational mill with different polymers (linear and crosslinked povidone, copovidone and sodium starch glycolate). An explorative analysis of formulation variables (drug-polymer wt ratio and polymer type) and process parameters (type of grinding media, grinding time and frequency) was carried out with the help of an experimental screening design. The influence of the above mentioned factors on three PZQ characteristics (residual crystallinity, water solubility enhancement and drug recovery) was studied. The variation of carrier amount proved to be by far the most important variable affecting all the experimental responses. A lower impact and, in some cases, rather null effect, had the variation of the process variables. All coground systems were characterized by a high amorphous degree and a solubility significantly higher than the API. A very promising product was obtained by processing at 20Hz for 4h, using 3 spheres of 15mm as grinding media, i.e. a coground having a 50% API content, showing a 4.6-fold greater solubility at 20°C than pure praziquantel. This product maintained the same antischistosomal ...
No abstract available
Authors: Kalkbrenner C, Brucher R, Kesztyüs T, Eichenlaub M, Rottbauer W, Scharnbeck D Abstract The current gold standard for assessment of most sleep disorders is the in-laboratory polysomnography (PSG). This approach produces high costs and inconveniences for the patients. An accessible and simple preliminary screening method to diagnose the most common sleep disorders and to decide whether a PSG is necessary or not is therefore desirable. A minimalistic type-4 monitoring system which utilized tracheal body sound and actigraphy to accurately diagnose the obstructive sleep apnea syndrome was previously develo...
Unusual "Worms" in the Small Intestine. Dtsch Arztebl Int. 2019 Mar 08;116(10):176 Authors: Graefe U, Keuchel M PMID: 30995959 [PubMed - in process]
Authors: Koch A PMID: 30995958 [PubMed - in process]
Authors: Mülder K, Stober HD, Hamacher W, Spiewok G, Pätel K PMID: 30995957 [PubMed - in process]
Authors: Beutner FU PMID: 30995956 [PubMed - in process]
Authors: Mehrholz J PMID: 30995955 [PubMed - in process]
Authors: Hömberg V PMID: 30995954 [PubMed - in process]
CONCLUSION: Putting these figures in the appropriate international context requires the acquisition of comparable data in multiple countries and is the main task of international TBI consortia. PMID: 30995953 [PubMed - in process]
Authors: Gensichen J, Hiller TS, Breitbart J, Brettschneider C, Teismann T, Schumacher U, Lukaschek K, Schelle M, Schneider N, Sommer M, Wensing M, König HH, Margraf J Abstract BACKGROUND: We evaluated a team-based program of exercises for patients with panic disorder with or without agoraphobia (PDA) in primary care. METHODS: 419 patients with PDA (mean age 46.2 years, standard deviation 14.4 years; 74% female) were included in this cluster-randomized, controlled intervention trial. The patients were blinded with respect to their group assignment at baseline. Patients in the intervention group (36 primary...