OR043 Obesity disrupts tissue-protective macrophage populations in the adipose and lung

Obesity causes significant morbidity and mortality by predisposing to diabetes, cancer, and atopy. Adipose tissue macrophages (ATMs) are critical for maintaining a lean state, but can contribute to adiposity and metabolic syndrome in some settings, raising questions as to the number of functionally distinct ATMs. Additionally, it is unknown the extent to which obesity influences tissue macrophages outside of adipose, a line of investigation that is important for understanding comorbid conditions.

Source: Annals of Allergy, Asthma and Immunology - October 27, 2017 Category: Allergy & Immunology Authors: D. Hill, H. Lim, Y. Foong, V. Nelson, K. Won, M. Lazar Source Type: research