CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis

AbstractThe cluster of differentiation protein complex, CD80/CD86, regulates Th1/Th2 differentiation in autoimmune disease. In order to establish the effects of CD80/CD86 on Th17 cell differentiation in acute viral myocarditis (VMC), we infected C57BL/6 mice with Coxsackie virus B3 (CVB3) and examined the effects of the treatment with anti-CD80/CD86 monoclonal antibodies (mAbs) on Th17 cell differentiationin vivo. The effects of anti-CD80/CD86 mAbs on Th17 cell differentiation were further evaluatedin vitro. The treatment with anti-CD80 mAb induced marked suppression of Th17 cell differentiation and ROR- γt mRNA expression, whereas anti-CD86 mAb alone had no effect, bothin vivo andin vitro. Our finding that CD80 regulates Th17 differentiation supports the potential utility of anti-CD80 mAb as an effective new immunotherapeutic target in acute VMC.
Source: Inflammation - Category: Allergy & Immunology Source Type: research