Are Circulating Type 2 Vaccine-Derived Polioviruses (VDPVs) Genetically Distinguishable from Immunodeficiency-Associated VDPVs?

We presented quantitative approaches using genetic information as a surveillance tool for early detection of VDPV outbreaks. This work suggests that genetic variations between cVDPV2 and iVDPV2 may reflect differences in viral micro-environments, host-virus interactions, and selective pressures during person-to-person transmission compared with chronic infections in immunodeficient patients.
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research