AI algorithm predicts lung disease, adverse events on CT

Recent studies have demonstrated the power of artificial intelligence (AI)...Read more on AuntMinnie.comRelated Reading: AI algorithm speeds up assessment of bone age How to develop deep-learning algorithms for radiology AI can yield patient-specific radiation dose estimates ISCT: The long road to full automation in abdominal CT Can AI accurately diagnose tuberculosis from chest x-rays?
Source: Headlines - Category: Radiology Source Type: news

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CONCLUSIONS: The QMAP system may serve as a useful screening method for identifying and accurately discriminating MTBC from non-tuberculous mycobacteria, as well as determining RIF- and INH-resistant MTB strains. PMID: 30027701 [PubMed - in process]
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
CONCLUSIONS: We determined the MICs of three anti-TB drugs for Korean MDR and XDR strains and identified various mutations in resistance-related genes. Further studies are needed to determine the genetic mechanisms underlying resistance to these drugs. PMID: 30027700 [PubMed - in process]
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
Tuberculosis still remains a leading cause of death in the world. Currently considerable interest in natural products and their derivatives in the area of drug research for multidrug resistant tuberculosis (MDR-TB). The present investigation focused on identification, isolation, characterization of lead constituents and to determine the antitubercular activity of their enriched fractions and isolated compounds by Nitrate reductase assay (NRA) method. Leaves extracted with ethanol by soxhlet extraction and ethanol extract separated in petroleum ether, chloroform and methanol by separating funnel and fractionated by column c...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
In this study Isoniazid (INH) as one of the first line drugs in treatment of Tuberculosis was investigated to be loaded in Solid Lipid Nanoparticles (SLNs) for reducing hepatotoxicity as well as prolonging drug release. High shear homogenization method was performed to prepare INH SLNs. To compare biodistribution of INH before and after loading in SLNs, INH was labeled by Technetium 99 (Tc99) after derivatization. The particle size of the prepared SLNs was 167 and 200 nm before and after lyophilization, respectively. Loading efficiency was calculated using the reverse method and release study was performed by using the dia...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
Abstract Drug resistance is still the major threat to global tuberculosis (TB) control, and drug-resistant (DR) Mycobacterium tuberculosis (M. tuberculosis) strains have become the main challenge worldwide. Currently used antibiotics for treatment of DR-TB are often poorly tolerated and not sufficiently effective. Since the therapeutic options are still limited, the main strategy for treatment of DR-TB is to repurpose existing anti-mycobacterial agents. Clofazimine (CFZ) is one such drug that has recently attracted interest against DR-TB. CFZ is a hydrophobic riminophenazine that was initially synthesized as an an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
This study sought to evaluate the levels of total serum cholesterol in the host following exposure to MAP. Blood samples were collected from both sheep and cattle prior to experimental challenge with MAP and at monthly intervals post-challenge. Total serum cholesterol levels in sheep challenged with MAP were significantly elevated at 9 weeks post-inoculation (wpi) in comparison to controls. When stratified based on disease outcome, there was no significant difference in serum cholesterol at the timepoints examined between MAP exposed sheep that were susceptible and those that were resistant to Johne’s disease. There ...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Publication date: Available online 20 July 2018Source: Journal of Microbiological MethodsAuthor(s): Carlos German Lemus-Minor, Diego Fernando Ovalle-Marroqui, J. Gustavo Vazquez-Jimenez, Diana Laura Reales-Agüero, Perla Michelle Sepulveda-Alcantara, Jesús René Rodriguez-Sánchez, Raúl Diaz-Molina, Jesús René Machado-ContrerasAbstractTuberculosis (TB) has a high incidence, prevalence and mortality in the world. Due to its high level of transmission and long-term pharmacological treatment, it is important to have sensitive and specific diagnostic tests. Recently, the PureLyse®...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
In this report, we review the current understanding of the pathogenesis, immunology, clinical epidemiology, diagnosis, treatment, and prevention of both incipient and subclinical TB, two emerging clinical states of an ancient bacterium. PMID: 30021818 [PubMed - in process]
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
Publication date: September 2018Source: Social Science &Medicine, Volume 212Author(s): Mishal S. Khan, Sonia Rego
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
PKC δ gene can induce macrophages to release inflammatory factors against Mycobacterium tuberculosis infection. Eur Rev Med Pharmacol Sci. 2018 Jul;22(13):4228-4237 Authors: Duan YT, Bi KY, Ma YS Abstract OBJECTIVE: To investigate the effect of PKC δ gene on the anti-tuberculosis activity of macrophages and the mechanism. MATERIALS AND METHODS: Bone marrow cells of PKC δ knockout mice and wild-type mice were cultured and L929 cells were induced to differentiate into macrophages. Lipopolysaccharide (LPS) and trehalose 6,6'-dimycolate (TDM) were used to stimulate macrophages respect...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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