AI algorithm predicts lung disease, adverse events on CT
Recent studies have demonstrated the power of artificial intelligence (AI)...Read more on AuntMinnie.comRelated Reading: AI algorithm speeds up assessment of bone age How to develop deep-learning algorithms for radiology AI can yield patient-specific radiation dose estimates ISCT: The long road to full automation in abdominal CT Can AI accurately diagnose tuberculosis from chest x-rays?
Abstract Tuberculosis remains a threat to public health. The major problem for curing this disease is latent infection, of which the underlying mechanisms are still not fully understood. Previous studies indicate that NK cells do not play a role in inhibiting the growth of Mycobacterium tuberculosis in the lung, and recent studies have revealed that NK cells regulate the adaptive immunity during mycobacterial infection. By using a mouse model of direct lung infection with M.bovis BCG, we found that the presence of NK cells postponed the priming and activation of T cells after BCG infection. In addition, depletion of NK cel...
Conclusion: This study identified a set of deregulated circRNAs in active TB PBMCs, our data also suggest that hsa_circRNA_001937 can be used as a potential diagnostic biomarker of TB.Cell Physiol Biochem 2018;45:1230 –1240
This study aims to compare the global prevalence of hepatitis B, hepatitis C, HIV, and tuberculosis in incarcerated adolescents and young adults (AYAs) and older prisoners.
MSF research shows that a combination of two new drugs can be used effectively to help patients with drug-resistant forms of tuberculosis.Language English
Contributors : Sharmila Nair ; Jeremy P Hyunh ; Vicky Lampropoulou ; Ekaterina Esaulova ; Ekaterina Loginicheva ; Anshu Gounder ; Adrianus C Boon ; Elizabeth A Schwarzkopf ; Tara R Bradstreet ; Brian T Edelson ; Maxim N Artyomov ; Christina L Stallings ; Michael S DiamondSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions principally in cells of myeloid lineage. Cell culture studies suggest that itaconate regulates inflammation through inhibitory effects on cytokine and reactive...
Authors: Vieira ACC, Chaves LL, Pinheiro M, Lima SAC, Ferreira D, Sarmento B, Reis S Abstract Tuberculosis (TB) is still a devastating disease and more people have died of TB than any other infectious diseases throughout the history. The current therapy consists of a multidrug combination in a long-term treatment, being associated with the appearance of several adverse effects. Thus, solid lipid nanoparticles (SLNs) were developed using mannose as a lectin receptor ligand conjugate for macrophage targeting and to increase the therapeutic index of rifampicin (RIF). The developed SLNs were studied in terms of diamete...
Antibodies against glycoprotein 2 display diagnostic advantages over ASCA in distinguishing CD from intestinal tuberculosis and intestinal Behçet's disease Clinical and Translational Gastroenterology 9, e133 (February 2018). doi:10.1038/ctg.2018.1 Authors: Shulan Zhang, Jing Luo, Ziyan Wu, Dirk Roggenbuck, Peter Schierack, Dirk Reinhold, Ji Li, Xiaofeng Zeng, Fengchun Zhang, Jiaming Qian &Yongzhe Li
Conclusion/SignificanceWe present the first national snapshot of theM.tuberculosis spoligotypes circulating in Nigeria based on ZN slides. Spoligotyping data can be obtained in a rapid and high-throughput manner with DNA extracted from ZN-stained slides, which may potentially improve our understanding of the genetic epidemiology of TB.
Conclusion Only a few diagnostic tests are useful for the etiological assessment of uveitis. They are often cheap, simple, more often guided by the clinical findings, and lead to an etiological diagnosis in most patients. On the other hand, some tests are never or exceptionally contributive, such as immunological tests or intracellular serologies. Further studies are required to evaluate the profitability of third intention imagery and invasive investigations.