Epidemiology and antifungal susceptibility of candidemia isolates of non-albicans Candida species from cancer patients

Epidemiology and antifungal susceptibility of candidemia isolates of non-albicans Candida species from cancer patients Emerging Microbes &Infections 6, e87 (October 2017). doi:10.1038/emi.2017.74 Authors: Ping-Feng Wu, Wei-Lun Liu, Min-Han Hsieh, Ing-Moi Hii, Yu-Lin Lee, Yi-Tsung Lin, Mao-Wang Ho, Chun-Eng Liu, Yen-Hsu Chen &Fu-Der Wang
Source: Emerging Microbes and Infections - Category: Infectious Diseases Authors: Tags: cancer epidemiology non-albicans candidemia susceptibility Source Type: research

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; Luiz Chambo Ricardo Miguel Costa de Freitas Berenice Bilharinho Mendonca Ana O. Hoff Madson Q. Almeida Isabel Weigand Matthias Kroiss Maria Claudia Nogueira Zerbini Maria Candida Barisson Villares Fragoso Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an unfavorable prognosis. Despite the poor prognosis in the majority of patients, no improvements in treatment strategies have been achieved. Therefore, the discovery of new prognostic biomarkers is of enormous interest. Sterol-O-acyl transferase 1 (SOAT1) is involved in cholesterol esterification and lipid droplet formation. Recently...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Interleukin-1 (IL-1) is a key mediator of inflammation and immunity. Naturally-occurring IL-1 receptor antagonist (IL-1Ra) binds and blocks the IL-1 receptor-1 (IL-1R1), preventing signaling. Anakinra, a recombinant form of IL-1Ra, is used to treat a spectrum of inflammatory diseases. However, anakinra is rapidly cleared from the body and requires daily administration. To create a longer-lasting alternative, PASylated IL-1Ra (PAS–IL-1Ra) has been generated by in-frame fusion of a long, defined-length, N-terminal Pro/Ala/Ser (PAS) random-coil polypeptide with IL-1Ra. Here, we compared the efficacy of two PAS–IL-...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Immunology Source Type: research
an Vu Reaction of 4-(1-adamantyl)-3-thiosemicarbazide (1) with numerous substituted acetophenones and benzaldehydes yielded the corresponding thiosemicarbazones containing adamantane skeletons. The synthesized compounds were evaluated for their in vitro activities against some Gram-positive and Gram-negative bacteria, and the fungus Candida albicans, and cytotoxicity against four cancer cell lines (Hep3B, HeLa, A549, and MCF-7). All of them showed good antifungal activity against Candida albicans. Compounds 2c, 2d, 2g, 2j and 3a, 3e, 3g displayed significant inhibitory activity against Enterococcus faecalis. Compoun...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
This study tentatively investigated the polyphenols profile of the stems of seven Mammillaria species (M. rhodantha, M. spinosissima, M. hahniana, M. crucigera, M. candida, M. albilanata, and M. muehlenpfordtii) using high performance liquid chromatography with DAD detector (HPLC-DAD) method. Furthermore, the anti-cancer, anti-oxidant, and anti-bacterial potentials of these extracts as well as major identified phenols were explored. The HPLC-DAD study confirmed the availability of six phenolic acids, including gentisic acid, chlorogenic acid, caffeic acid, protocatechuic acid, sinapic acid, and p-hydroxybenzoic acid. The d...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
This study retrospectively analyzed the clinical data of 411 patients with lung cancer who were hospitalized in the First Affiliated Hospital of Zhejiang University Medical College from January 2017 to December 2018, and counted the incidence of nosocomial lung infection, pathogens, drug resistance and influencing factors. Results There were 184 cases of nosocomial pulmonary infection in 411 lung cancer patients during chemotherapy, the infection rate was 44.77%. The isolated pathogens included Gram-negative bacteria, Gram-positive bacteria, viruses, fungi and tuberculosis, among which Gram-negative bacteria accounted for ...
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Publication date: Available online 13 December 2019Source: Inorganica Chimica ActaAuthor(s): Sonja Ž. Đurić, Marija Mojicevic, Sandra Vojnovic, Hubert Wadepohl, Tina P. Andrejević, Nevena Lj. Stevanović, Jasmina Nikodinovic-Runic, Miloš I. Djuran, Biljana Đ. GlišićAbstractIn a continuing search for a novel metal-containing antimicrobial agents, the present study reports the synthesis, characterization and biological evaluation of two silver(I) complexes with 1,10-phenanthroline-based ligands, [Ag(1,10-phen)2]CF3COO.H2O (Ag1) and [Ag(CF3COO)(5,6-epoxy-1,10-phen)]2 (Ag2), 1,10-phen is 1,10-phenanthroline...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
There are only few drugs available to treat fungal infections, and the lack of new antifungals, along with the emergence of drug-resistant strains, results in millions of deaths/year. An unconventional approach to fight microbial infection is to exploit nutritional vulnerabilities of microorganism metabolism. The metal gallium can disrupt iron metabolism in bacteria and cancer cells, but it has not been tested against fungal pathogens such as Aspergillus and Candida. Here, we investigate in vitro activity of gallium nitrate III [Ga(NO3)3] against these human pathogens, to reveal the gallium mechanism of action and understa...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Synthesis, cytotoxicity and antimicrobial evaluation of new coumarin-tagged β-lactam triazole hybrid. Chem Biodivers. 2019 Dec 01;: Authors: Dhawan S, Awolade P, Kisten P, Cele N, Pillay AS, Saha ST, Kaur M, Jonnalagaddas SB, Singh P Abstract A series of coumarin-tagged β-lactam triazole hybrids ( 10a - o ) were synthesized and tested for their cytotoxic activity against MDA-MB-231 (triple negative breast cancer), MCF-7 (estrogen receptor positive breast cancer (ER+) and A549 cells (human lung carcinoma) cancer cell lines including a normal cell line, HEK-293 (human embryonic kidney). Two co...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research
McNeil Blair Domínguez-Álvarez Selenoesters and the selenium isostere of phthalic anhydride are bioactive selenium compounds with a reported promising activity in cancer, both due to their cytotoxicity and capacity to reverse multidrug resistance. Herein we evaluate the antiviral, the biofilm inhibitory, the antibacterial and the antifungal activities of these compounds. The selenoanhydride and 7 out of the 10 selenoesters were especially potent antiviral agents in Vero cells infected with herpes simplex virus-2 (HSV-2). In addition, the tested selenium derivatives showed interesting antibiofilm act...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Fungal infections have increased in the last few decades as a result of the use of broad-spectrum antibiotics and the growing number of immunocompromised patients (pts), which have led to changes in the saprophytic microorganisms usually isolated. Fungal empyema (FE) is still a rare entity, with a mortality rate of 70%. Retrospective analysis of fungal pleural effusions diagnosed in our hospital between 2015 and 2018. Aseptic sampling of pleural fluid was performed by thoracentesis, chest drainage (CT) or video-assisted thoracoscopic surgery (VATS). Seventeen fungal isolates were obtained from 15 pts (12 males, mean age 60...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
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