Characterization and use of the novel human multiple myeloma cell line MC-b11/14 to study biological consequences of CRISPR-mediated loss of immunoglobulin a heavy chain

• A novel human monoclonal IgA kappa myeloma cell line was established.• CRISPR mediated gene editing was used to disrupt IgA heavy chain expression.• Loss of IgA expression, significantly lessened sensitivity to bortezomib.

Source: Experimental Hematology - October 10, 2017 Category: Hematology Authors: Denise K. Walters, Bonnie K. Arendt, Renee C. Tschumper, Xiaosheng Wu, Diane F. Jelinek Source Type: research