The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms

House dust mite (HDM) is the most common cause of allergic sensitization in many countries worldwide1 and allergic asthma is strongly associated with HDM sensitization.2 Treatment with the SQ HDM sublingual immunotherapy (SLIT) tablet (12 SQ-HDM) significantly improves allergic rhinoconjunctivitis symptoms, reduces the risk of moderate or severe asthma exacerbations, and decreases inhaled corticosteroid use in subjects with HDM allergic asthma.3-7 SLIT is likely to modify T- and B-lymphocyte populations, resulting in an increase in local regulatory pathways, including the production of cytokines that inhibit allergic inflammation.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research