Therapeutic Drug Monitoring Simulator for Antibiotic Dosage for Methicillin-Resistant Staphylococcus aureus Sepsis in a Patient with Primary Immunodeficiency on Peritoneal Dialysis.

Therapeutic Drug Monitoring Simulator for Antibiotic Dosage for Methicillin-Resistant Staphylococcus aureus Sepsis in a Patient with Primary Immunodeficiency on Peritoneal Dialysis.
J Nippon Med Sch. 2017;84(4):177-182
Authors: Narazaki H, Terada Y, Kaizu K, Jitsukawa T, Ito Y, Asano T
Abstract
Bacterial infections often cause fatal systemic infections in patients with primary immunodeficiency. To prevent unfortunate results, the selection, dose, and dosage of antibiotics are extremely important. Here, we report a case of Wiskott-Aldrich syndrome in a patient undergoing peritoneal dialysis because of chronic renal failure in whom methicillin-resistant Staphylococcus aureus sepsis developed. Because of the primary disease and complications, teicoplanin was the only chosen anti-S. aureus drug to prevent side effects. We used parameter estimation and dosage adjustment from a therapeutic drug monitoring simulation software program to overcome the challenges with teicoplanin treatment.
PMID: 28978898 [PubMed - in process]

Source: Journal of Nippon Medical School - October 6, 2017 Category: Universities & Medical Training Authors: Narazaki H, Terada Y, Kaizu K, Jitsukawa T, Ito Y, Asano T Tags: J Nippon Med Sch Source Type: research