Sugar hydrazide imides: a new family of glycosidase inhibitors

Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01673E, CommunicationEmil Lindback, Oscar Lopez, Adne Tobiesen, Jose G Fernandez-Bolanos, Magne Olav Sydnes The preparation of a novel type of iminosugars including a hydrazide imide moiety is described. The sugar hydrazide imides (3S,4S,5R,6R)-1-amino-3,4,5-trihydroxy-6-(hydroxymethyl)-2-iminopiperidine acetate and (3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-1-(methylamino)-2-iminopiperidine acetate presented behave as inhibitors of [small alpha]/[small beta]-glucosidases... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - October 6, 2017 Category: Molecular Biology Authors: Emil Lindback Source Type: research