Two new lactones from whole herbs of Patrinia villosa Juss

Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Ming Bai, Si-Fan Liu, Wei Wang, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song Chemical investigation of 70% EtOH exact of Patrinia villosa Juss. led to the isolation, purification and identification of two new lactones (1-2) along with twelve known compounds (3-14). Their structures were established by comprehensive spectroscopic analyses. All compounds were evaluated for their cytotoxic activities against A549, HepG2, Hep3B and MCF-7 cancer cell lines. Compounds 1, 8, 10, 11 and 12 displayed weak cytotoxic activities against MCF-7 cell line. In addition, compounds 1, 2, 8, 10, 11 and 12 were also tested their antimicrobial activities against Micrococcus luteus. Unfortunately, these compounds were found to be inactive. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research