C(sp(3))-H amination of 8-methylquinolines with azodicarboxylates under Rh(iii) catalysis: cytotoxic evaluation of quinolin-8-ylmethanamines.

C(sp(3))-H amination of 8-methylquinolines with azodicarboxylates under Rh(iii) catalysis: cytotoxic evaluation of quinolin-8-ylmethanamines.
Chem Commun (Camb). 2017 Sep 28;:
Authors: Jeong T, Kumar Mishra N, Dey P, Oh H, Han S, Hun Lee S, Sik Kim H, Park J, Su Kim I
Abstract
The rhodium(iii)-catalyzed C(sp(3))-H amination reaction of 8-methylquinolines and azodicarboxylates is described. A cationic rhodium catalyst in the presence of lithium acetate and lithium carbonate was found to be an optimal catalytic system for the construction of quinolin-8-ylmethanamine derivatives, which were evaluated for in vitro cytotoxicity against human breast adenocarcinoma cells (MCF-7) and human prostate adenocarcinoma cells (LNCaP).
PMID: 28956557 [PubMed - as supplied by publisher]

Source: Chemical Communications - September 28, 2017 Category: Chemistry Authors: Jeong T, Kumar Mishra N, Dey P, Oh H, Han S, Hun Lee S, Sik Kim H, Park J, Su Kim I Tags: Chem Commun (Camb) Source Type: research