Outcomes of patients with relapsed core binding factor-positive acute myeloid leukemia
Patients with CBF-AML who relapse have suboptimal outcomes. We retrospectively analyzed 92 CBF-AML patients at first relapse to identify factors associated with clinical outcome. Age, high white cell count, high bone marrow blast percentage and t(8;21) cytogenetic group were associated with worse prognosis. Our findings suggest that consideration of these factors, especially t(8;21) cytogenetics, can improve prognostic stratification of patients.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Maliha Khan, Jorge Cortes, Wei Qiao, Mohanad A. Alzubaidi, Sherry A. Pierce, Farhad Ravandi, Hagop M. Kantarjian, Gautam Borthakur Source Type: research