Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy.

Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy.
Radiother Oncol. 2017 Sep 19;:
Authors: Stam B, van der Bijl E, van Diessen J, Rossi MMG, Tijhuis A, Belderbos JSA, Damen E, Sonke JJ
Abstract
Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V2Gy:HR=1.007%(-1) (95% CI:1.002-1.013; p=0.006), age:HR=1.026year(-1) (1.011-1.042; p=0.001) and GTV volume:HR=1.001cc(-1) (1.000-1.002; p=0.006) with overall survival.
PMID: 28939179 [PubMed - as supplied by publisher]

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 19, 2017 Category: Radiology Authors: Stam B, van der Bijl E, van Diessen J, Rossi MMG, Tijhuis A, Belderbos JSA, Damen E, Sonke JJ Tags: Radiother Oncol Source Type: research