Characteristics and clinical outcomes of pleomorphic lobular carcinoma in situ of the breast

Abstract Pleomorphic lobular carcinoma in situ (PLCIS) of the breast is a rare variant of lobular carcinoma in situ (LCIS). We reviewed 78 cases of PLCIS diagnosed at our institution from 1998 to 2012. Among all cases, 47 (60%) were associated with invasive carcinoma and/or ductal carcinoma in situ (DCIS) after final surgical excision. Of the 20 cases with PLCIS alone on core needle biopsy (CNB), 6 (30%) were upgraded to invasive carcinoma or DCIS after final surgical excision. Our findings support a recommendation for complete surgical excision of PLCIS when diagnosed on CNB.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Ftbj.12843

Source: The Breast Journal - September 19, 2017 Category: Cancer & Oncology Authors: Carolina E. Fasola, Jie Jane Chen, Kristin C. Jensen, Kimberly H. Allison, Kathleen C. Horst Tags: SHORT COMMUNICATION Source Type: research