Poster 96: Additive Effects of β-3 Agonist (Mirabegron) for Treatment of Neurogenic Detrusor Overactivity in Spinal Cord Injury Patients who had been Treated with Antimuscarinic Agent

Jeong-Hwan Seo: I Have No Relevant Financial Relationships To Disclose
Source: PM and R - Category: Rehabilitation Authors: Source Type: research

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Authors: Fogarty MJ, Sieck GC Abstract Introduction: Neuromotor control of diaphragm muscle and the recovery of diaphragm activity following spinal cord injury has been narrowly focused on ventilation. By contrast, the understanding of neuromotor control for non-ventilatory expulsive/straining maneuvers (including coughing, defecation and parturition) is relatively impoverished. This variety of behaviours is achieved via the recruitment of the diverse array of motor units that comprise the diaphragm muscle.Areas covered: The neuromotor control of ventilatory and non-ventilatory behaviors in health and in the contex...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
ConclusionOur results demonstrate that either Endomorphin-1 or CGRP receptor antagonist is able to decrease the neuropathic pain after SCI but combination therapy by a CGRP receptor antagonist and Endomorphin-1 did not make any further reduction in pain sensation.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
CONCLUSION: We conclude that CEUS has the spatial and temporal sensitivity and resolution to visualize local tissue perfusion and vessel architecture, which maybe useful clinically to determine injury extent and severity in patients with SCI. PMID: 32074323 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Journal of Neurotrauma, Ahead of Print.
Source: Journal of Neurotrauma - Category: Neurology Authors: Source Type: research
Spinal Cord, Published online: 21 February 2020; doi:10.1038/s41393-020-0439-1The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial
Source: Spinal Cord - Category: Research Authors: Source Type: research
Glial signals are known to inhibit axonal regeneration and functional recovery after mammalian central nervous system trauma, including spinal cord injury. Such signals include membrane-associated proteins of the oligodendrocyte plasma membrane and astrocyte-derived, matrix-associated proteins. Here, using cell lines and primary cortical neuron cultures, recombinant protein expression, immunoprecipitation and immunoblot assays, transmission EM of exosomes, and axon regeneration assays, we explored the secretion and activity of the myelin-associated neurite outgrowth inhibitor Nogo-A and observed exosomal release of a 24-kD...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Source Type: research
The protein Nogo-A has been widely studied for its role in inhibiting axonal regeneration following injury to the central nervous system, but the mechanism by which the membrane-bound Nogo-A is presented intercellularly is not fully understood. New research suggests that a highly inhibitory fragment of Nogo-A is generated by the amyloid precursor protein protease BACE1 and presented on the membranes of exosomes following spinal cord injury. This finding represents a new mode through which Nogo-A may exert its effects in the central nervous system.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Highlights Source Type: research
ConclusionsDespite published reports showing benefit for pain control in patients with BPA, the overall low quality, retrospective evidence included in this review highlights the need for a rigorous prospective study to further address this indication.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Review Article Source Type: research
Ventilators are used by patients who lose lung function due to complications from a variety of diseases such as spinal cord injuries, COPD, stroke, pneumonia, and ALS. In addition to dealing with a debilitating situation, patients tend to be hooked t...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Critical Care Exclusive Medicine Pediatrics Rehab Source Type: blogs
Central neuropathic pain (CNP) after spinal cord injury (SCI) is debilitating and immensely impacts the individual. Central neuropathic pain is relatively resistant to treatment administered after it develops, perhaps owing to irreversible pathological processes. Although preemptive treatment may overcome this shortcoming, its administration necessitates screening patients with clinically relevant biomarkers that could predict CNP early post-SCI. The aim was to search for such biomarkers by measuring pronociceptive and for the first time, antinociceptive indices early post-SCI. Participants were 47 patients with acute SCI ...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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