Complement C5a receptors C5L2 and C5aR in renal fibrosis.

In conclusion, in experimental renal fibrosis C5L2 and C5aR both contribute to tubular injury, and, while C5aR acts profibrotic, C5L2 does not play a role in extracellular matrix accumulation, arguing against C5L2 functioning simply as a decoy receptor.
PMID: 28903945 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - September 13, 2017 Category: Urology & Nephrology Authors: Martin IV, Bohner A, Boor P, Shagdarsuren E, Raffetseder U, Lammert F, Floege J, Ostendorf T, Weber SN Tags: Am J Physiol Renal Physiol Source Type: research