Discrepant susceptibility to gentamicin despite amikacin resistance in Klebsiella pneumoniae by VITEK 2 represents false susceptibility associated with the armA 16S rRNA methylase gene.
Discrepant susceptibility to gentamicin despite amikacin resistance in Klebsiella pneumoniae by VITEK 2 represents false susceptibility associated with the armA 16S rRNA methylase gene. J Med Microbiol. 2017 Sep 12;: Authors: Ko JH, Baek JY, Peck KR, Cho SY, Ha YE, Kim SH, Huh HJ, Lee NY, Kang CI, Chung DR, Song JH Abstract Because we experienced gentamicin failure in Klebsiella pneumoniae bacteraemia that was susceptible to gentamicin despite amikacin resistance, as determined by VITEK 2, we evaluated the true susceptibility and mechanism of resistance. We screened 2818 K. pneumoniae isolates during a 1-year period at a university hospital and reviewed anti-microbial susceptibility reports using the VITEK 2 system. The minimum inhibitory concentration was substantiated by broth microdilution (BMD), and the presence of 16S rRNA methylase genes and aminoglycoside-modifying enzymes was also investigated. A total of 131 amikacin-resistant isolates from 19 patients were gentamicin non-resistant according to the VITEK 2 system. Among these, we were able to collect isolates from 12 patients (63.2 %), and a single isolate from each patient was tested. Eleven of the gentamicin non-resistant isolates (91.7 %) showed high-level resistance to both amikacin and gentamicin by BMD in association with the armA gene. Gentamicin is not an adequate treatment option for amikacin-resistant K. pneumoniae, even if VITEK 2 reports susceptibility. PMID: 28893358 [PubMe...
At least 22 people have developed some type of respiratory illness after vaping or using e-cigarettes
HIGH blood pressure is a common condition in the UK. Making certain lifestyle tweaks can help to lower a soaring reading. According to a recent study, a popular juice may also do the trick.
Review of "Atlas of Artifacts in Clinical Neurophysiology," by William O. Tatum, IV Atlas of Artifacts in Clinical Neurophysiology by William O. Tatum , IV, Demos Medical Publishing, 2018 , 419 pages. ISBN: 9780826169341 . E-book ISBN: 978-0826169358 . List Price: $185.00; Amazon New: $154.02; Amazon Used: $144.00; Kindle: $129.36. Neurodiagn J. 2019 Aug 23;:1-2 Authors: Clark-Bash RJ PMID: 31441708 [PubMed - as supplied by publisher]
Authors: Moosavian SP, Arab A, Mehrabani S, Moradi S, Nasirian M Abstract Background: Several studies have investigated the effect of omega-3 fatty acids and vitamin E on oxidative stress and inflammation, but their findings are inconsistent. The aim of this meta-analysis is to elucidate the overall effects of co-supplementation with omega-3 fatty acids and vitamin E on oxidative stress and inflammation. Methods: We searched titles, abstracts, and keywords of relevant articles indexed in PubMed, ISI, Scopus, and Google Scholar databases up to December 2018 to identify eligible RCT studies. Random effects model was...
Conclusion: These results provide a potential mechanism involving AMPK activation/ROS inhibition signaling pathway in osteogenic differentiation of BMSCs enhanced by resveratrol. It suggests that development of therapy towards ROS is an effective way for osteoporosis treatment. PMID: 31438780 [PubMed - in process]