Temporal Image Comparison (Serial Imaging) in Assessing Pigmented Lesions.
Temporal Image Comparison (Serial Imaging) in Assessing Pigmented Lesions. Dermatol Clin. 2017 Oct;35(4):447-451 Authors: Drugge RJ, Drugge ED Abstract The large-scale deployment of low-cost, noninvasive mechanisms of early detection are needed to reduce the melanoma burden. A serial 2-step system could power mass screening efforts serving the uninsured and underinsured as well as the rural and remote US counties where melanoma mortality is doubled for lack of access to dermatologists. Furthermore, serial melanoma screening strategies, serial total body photography and serial digital dermatoscopy imaging may be performed as a telehealth service, and thus would be available in any location that can support activity compliant with the Health Insurance Portability and Accountability Act and has appropriate bandwidth. PMID: 28886800 [PubMed - in process]
Authors: Setsu T, Tsuchiya A, Terai S PMID: 32213762 [PubMed - as supplied by publisher]
Publication date: Available online 27 March 2020Source: International Journal of PharmaceuticsAuthor(s): Hongmei Lin, Longfei Lin, Yoonsun Choi, Bozena Michniak-Kohn
We report a case of a 48-year-old woman with 9 months of rectal swelling and bleeding. Physical examination revealed a mass about 5 × 6 cm on the anterior wall of the rectum, 3 cm from the anal verge, and the patient underwent abdominoperineal resection (APR). After hematoxylin-eosin staining and immunohistochemical staining, it was considered an ARM, which is an aggressive disease with a poor survival. Immunohistochemical staining showed the tumor to be positive for S-100, Melan A, Ki67 proliferative index of 70%, and negative for HMB45. The melanoma had infiltrated the adventitia and metastasized to the (intestinal...
CONCLUSIONS IFN-alpha1b has an immunostimulatory activity similar to IFN-alpha2b and possesses milder adverse effects on immune checkpoints and stronger inhibitory effects on melanoma cell growth than IFN-alpha2b. Therefore, IFN-alpha1b is a promising drug for the treatment of melanoma. PMID: 32210221 [PubMed - in process]
Since melanocytes are the origin of melanoma and some skin disorders such as melasma, they are important cells from the perspective of medicinal chemistry. Therefore, a medication that can simultaneously overcome these diseases will be a successful potential therapeutic agent. Arbutin with phenolic structure is a powerful natural anti-tyrosinase agent. Hence, the phenolic structure of this drug, prompted us to design its novel calixarene-based cluster. Therefore, the present study reports the synthesis and in vitro bio-activities of cyclic tetramer of arbutin in comparison to its simple drug unit as the reference medica...
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b23177
Multiple studies have reported on the accuracy of the prognostic 31-gene expression profile test (31-GEP) for cutaneous melanoma. Consistency of the test results across studies has not been systematically evaluated.
Carmona-Sáez Rodríguez-Manzaneque Extracellular matrix remodeling within the tumor microenvironment has been recognized as a relevant dynamic framework during tumor growth. However, research on proteases that trigger this remodeling keeps revealing a wide range of actions including both pro- and anti-tumorigenic. The extracellular protease ADAMTS1 exemplifies this dual role. In this work, we first confirmed a positive correlation of ADAMTS1 with endothelial-like phenotype of human melanoma cells together with the finding of associated signatures, including key genes such as endothelial CDH5. Using a C...
In this study, Hyp photophysical... The content of this RSS Feed (c) The Royal Society of Chemistry