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CD101, a long-acting echinocandin, and comparator antifungal agents tested against a global collection of invasive fungal isolates in the SENTRY 2015 Antifungal Surveillance Program.

Int J Antimicrob Agents. 2017 Sep;50(3):352-358. doi: 10.1016/j.ijantimicag.2017.03.028.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
This study explores the possible application of biogenic silver nanoparticles produced from gum kondagogu as potent antifungal agents. The potent antifungal activity of Gk-AgNPs gives scope for its relevance in biomedical application and as a seed dressing material.
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Conclusions UV-C disinfection system was effective in killing MDR pathogens. Further study is warranted to confirm its effectiveness as an adjunctive method in disinfecting hospital environment.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Publication date: Available online 18 September 2017 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): M. Sankarganesh, P. Adwin Jose, J. Dhaveethu Raja, M.P. Kesavan, M. Vadivel, J. Rajesh, R. Jeyamurugan, R. Senthil Kumar, S. Karthikeyan In this research work, we have synthesized new pyrimidine based Schiff base ligand, 2-((4,6-dimethoxypyrimidine-2-yl)methyleneenamino)-6-methoxyphenol (DPMM) capped gold (Au) and platinum (Pt) nanoparticles (NPs) by modified Brust-Schiffrin method. The characteristics of DPMM-Au NPs and DPMM-Pt NPs have been examined by UV–Visible, FTIR, SEM, TEM and powder X...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Mon, 09/18/2017 - 15:12News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conclusions: A precise and highly sensitive liquid chromatography-tandem mass spectrometry method was developed that enables quantification of triazoles in plasma and serum matrix across therapeutically relevant concentration ranges. It was successfully implemented in our therapeutic drug monitoring routine service and is suitable for routine monitoring of antifungal therapy and in severely ill patients.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
er O Abstract The incidence of azole resistance in Aspergillus species has increased over the past years, most importantly for Aspergillus fumigatus. This is partially attributable to the global spread of only a few resistance alleles through the environment. Secondary resistance is a significant clinical concern, as invasive aspergillosis with drug-susceptible strains is already difficult to treat, and exclusion of azole-based antifungals from prophylaxis or first-line treatment of invasive aspergillosis in high-risk patients would dramatically limit drug choices, thus increasing mortality rates for immunocomprom...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
In this study, high-throughput RNA-seq was used to investigate salt stress-induced genes in the parent, ΔcnaB, and ΔcnaBΔcchA strains of Aspergillus nidulans, which differ greatly in salt adaption. In total, 2,884 differentially expressed genes including 1,382 up- and 1,502 downregulated genes were identified. Secondary transporters, which were upregulated to a greater extent in ΔcnaBΔcchA than in the parent or ΔcnaB strains, are likely to play important roles in response to salt stress. Furthermore, 36 genes were exclusively upregulated in the ΔcnaBΔcchA under salt stress. F...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Zuzana Hruska, Haibo Yao, Russell Kincaid, Robert L. Brown, Deepak Bhatnagar, Thomas E. Cleveland
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
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