Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls.

CONCLUSIONS: Circulating PR3-specific B cells can be detected in HC and patients with PR3-AAV. Their progressive enrichment during B-cell maturation suggests that they are actively selected and escape peripheral tolerance checkpoints in patients.
PMID: 28870527 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - September 1, 2017 Category: Allergy & Immunology Authors: Cornec D, Berti A, Hummel A, Peikert T, Pers JO, Specks U Tags: J Autoimmun Source Type: research