Lung deposition and systemic bioavailability of different aerosol devices with and without humidification in mechanically ventilated patients

During mechanical ventilation medical aerosol delivery has been reported to be upto two fold greater with dry inhaled gas than with heated humidity. Urine levels at 0.5  h post dose (URSAL0.5%) has been confirmed as an index of lung deposition and 24 h (URSAL24%) as index of systemic absorption.Our aim was to determine the effect of humidification and aerosol device type on drug delivery to ventilated patients using urine levels.

Source: Heart and Lung - September 4, 2017 Category: Intensive Care Authors: Islam O.F. Moustafa, Mohammed R. A.-A. Ali, Moataz Al Hallag, Hoda Rabea, James B. Fink, Patricia Dailey, Mohamed E.A. Abdelrahim Source Type: research