Boy battling blood disease dies 24 hours after contracting 'infection'

Toddler Max Moment, from Lancashire, died after developing a deadly infection after months of chemotherapy to treat Langerhans Cell Histiocytosis. Just weeks before his death doctors told his parents he was in remission and beating the rare disease.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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This study was supported by the Shanghai Sailing Program [grant number 17YF1425200, 2017]; Chinese National Natural Science Funding [grant number 81702249, 2017]; Science and Technology Commission of Shanghai Municipality [grant number 17511103403, 2017]; The funder has no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We acknowledge the ex...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThe particularity of this observation is the bilaterality of the lesion on both forearms and it has not previously been reported. Langerhans cell histiocytosis should be included in the differential diagnosis of osteomyelitis and Ewing ’s sarcoma.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusions: PET has been shown to be superior to bone scintigraphy and skeletal survey for overall lesion detection. Patients with LCH involving only the bones have a significantly better outcome than those with other organ involvement. Results of this study suggest that F-18 FDG PET/CT is useful for identification of active lesions, stratification of disease stages, monitoring of therapeutic response, and detection of reactivation in LCH patients.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Pediatrics Posters Source Type: research
We describe the difficulties with the diagnosis and treatment of LCH as well as successful treatment with cladribine chemotherapy and allogeneic stem cell transplantation. PMID: 29716681 [PubMed - in process]
Source: Acta Medica: Hradec Kralove - Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research
Publication date: Available online 31 July 2017 Source:Interdisciplinary Neurosurgery Author(s): Joshua Y. Chua, Ji Min Ling, Derrick W.Q. Lian, Mei Yoke Chan, David C.Y. Low, Sharon Y.Y. Low Langerhans Cell Histiocytosis is a rare disease featuring aberrant proliferation of dendritic cells that can infiltrate the bony skeleton. The authors report a case of six-year-old female presenting with torticollis. She was found to have extensive lytic LCH lesions in the cranio-cervical junction, causing atlanto-axial rotatory subluxation. Decision was made for a non-surgical approach to treat the patient. She was placed in a Halo ...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Authors: Radzikowska E, Wiatr E, Franczuk M, Bestry I, Roszkowski-Śliż K Abstract Pulmonary Langerhans cell histiocytosis (LCH) is a rare disease, affecting usually young people. The course of the disease is variable. In some pulmonary LCH patients a severe lung destruction and progression in spite of chemotherapy is observed, but in others just a cessation of smoking induces a regression of the disease. In the present study we seek to determine the influence of pregnancy on pulmonary function in LCH patients, an unchartered area of research. We addressed the issue by investigating eight pregnant women out of the...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Vinblastine is the standard treatment for children with Langerhans cell histiocytosis (LCH). Whether this treatment could be extended to adults with LCH is questionable. This retrospective multicenter study in...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Source Type: research
Publication date: Available online 10 May 2017 Source:Journal of Coloproctology Author(s): Bruno Lorenzo Scolaro, Gustavo Becker Pereira, Daniel Cury Ogata, Fernanda Souto Padrón Figueiredo Vieira da Cunha, Ana Cristina Martins Effting, Rafael Oselame Guanabara Langerhans’ cell histiocytosis is a rare disease characterized by proliferation of Langerhans cells in the body. It affects mainly males, predominantly in childhood. Ulcerated plaques are one of the cutaneous forms of presentation. Diagnostic confirmation is done through immunohistochemistry. As therapeutic options, topical corticosteroids and chemothe...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Klin Padiatr 2016; 228: 294-306 DOI: 10.1055/s-0042-109713Rare histiocytoses, also called non-Langerhans cell histiocytoses, include all proliferative disorders of histiocytes, macrophages and dendritic cells that are not classified as Langerhans cell histiocytosis (LCH) and do not belong to the hemophagocytic lymphohistiocytosis (HLH) group of diseases. Thus, the term includes numerous benign or malignant, localized or systemic, adult or pediatric diseases. The classification of the histiocytic disorders has been revised several times. Here, we follow the classification recently published by Jean Francois Emile and an int...
Source: Klinische Padiatrie - Category: Pediatrics Authors: Tags: Review Source Type: research
Abstract Langerhans cell histiocytosis (LCH) is a rare disease affecting both genders and can occur at any age. It often evolves through successive flares, and its severity varies from benign forms that don't require treatment to life threatening disease. Some patients have important functional impairment with psychological and social consequences and prolonged disability. LCH may affect only one organ, with uni- or multifocal involvement or be multisystem disease involving multiple organs. The organs most frequently involved are bones, lung, skin and the endocrinal system. Pulmonary LCH is strongly related to smo...
Source: Presse Medicale - Category: Journals (General) Authors: Tags: Presse Med Source Type: research
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