Biologically feasible gene trees, reconciliation maps and informative triples.

Biologically feasible gene trees, reconciliation maps and informative triples. Algorithms Mol Biol. 2017;12:23 Authors: Hellmuth M Abstract BACKGROUND: The history of gene families-which are equivalent to event-labeled gene trees-can be reconstructed from empirically estimated evolutionary event-relations containing pairs of orthologous, paralogous or xenologous genes. The question then arises as whether inferred event-labeled gene trees are biologically feasible, that is, if there is a possible true history that would explain a given gene tree. In practice, this problem is boiled down to finding a reconciliation map-also known as DTL-scenario-between the event-labeled gene trees and a (possibly unknown) species tree. RESULTS: In this contribution, we first characterize whether there is a valid reconciliation map for binary event-labeled gene trees T that contain speciation, duplication and horizontal gene transfer events and some unknown species tree S in terms of "informative" triples that are displayed in T and provide information of the topology of S. These informative triples are used to infer the unknown species tree S for T. We obtain a similar result for non-binary gene trees. To this end, however, the reconciliation map needs to be further restricted. We provide a polynomial-time algorithm to decide whether there is a species tree for a given event-labeled gene tree, and in the positive case, to construct the species...
Source: Algorithms for Molecular Biology : AMB - Category: Molecular Biology Authors: Tags: Algorithms Mol Biol Source Type: research