Inflammation-induced stress hematopoiesis

Infections are associated with extensive consumption of differentiated hematopoietic cells, representing a high risk for health. However, the mechanism coordinating the rapid and efficient regeneration of these differentiated cells during such stress conditions remains unclear. Recently, we have reported that the phenotypic hematopoietic stem cell (HSC) compartment contains stem-like megakaryocyte-committed progenitors (SL-MkPs), a cell population that shares many features with multipotent HSCs and serves as a lineage-restricted emergency pool for inflammatory insults.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research