Assessment of ER stress in mesenchymal stem cells from healthy and obese bone marrow donors

The Endoplasmic Reticulum (ER) is involved in processing and transporting proteins. When misfolded proteins accumulate in the ER, the cell enters a process called “ER stress”. ER stress results in the activation of pathways that will result in clearance of ER stress or if unresolved in cell death through autophagy or apoptosis. Prolonged ER stress in stem cells may result in loss of stemness. Mesenchymal stem cells (MSCs) are adult multipotent stromal tis sue stem cells, that can be isolated from the bone marrow.

Source: Experimental Hematology - August 22, 2017 Category: Hematology Authors: Baris Ulum, Hikmet Taner Teker, G ünay Balta, Duygu Uçkan-Çetinkaya, Fatima Aerts-Kaya Source Type: research