LDL4: a novel predictor of coronary artery disease severity.

LDL4: a novel predictor of coronary artery disease severity. Curr Med Res Opin. 2017 Aug 08;:1-17 Authors: Chaudhary R, Mathew D, Bliden K, Tantry US, Sharma T, Gesheff MG, Franzese CJ, Pandya S, Toth PP, Gurbel PA Abstract BACKGROUND: Hyperlipidemia is a well-established risk factor for coronary artery disease (CAD). Severe CAD has been observed in patients with normal levels of total and LDL cholesterol. Small-dense LDL particle subtypes (LDL3 and LDL4) have been observed to be more oxidizable and atherogenic. We aimed to identify the role of cholesterol particle subtypes in predicting CAD severity. METHODS: Blood samples were obtained immediately before cardiac catheterization in 179 consecutive patients with suspected CAD. Detailed lipid profiling was performed using VAP cholesterol test. CAD severity was categorized angiographically as none/minor CAD (75% LDS of any major coronary vessel). RESULTS: Patients with severe CAD had significantly higher LDL4, triglycerides, and lower total HDL, HDL2, HDL3, LDL2 and LDL3 compared to patients with none/minor CAD (p 
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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This study clearly goes against what has been the common wisdom for the last 30, 40 years” and may lead to less testing and invasive treatment for such patients in the future, said Dr. Glenn Levine, a Baylor College of Medicine cardiologist with no role in the research. Some doctors still may quibble with the study, but it was very well done “and I think the results are extremely believable,” he said. About 17 million Americans have clogged arteries that crimp the heart’s blood supply, which can cause periodic chest pain. Cheap and generic aspirin, cholesterol-lowering drugs and blood pressure medic...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime Research Source Type: news
Conclusion: Early rule out protocol is effective and safe.We refer interested readers to the following excellent reviews of high-sensitivity troponin implementation:Twerenbold, R. et al.JACC70 (8): 996 –1012.https://doi.org/10.1016/j.jacc.2017.07.718.Yader S. et al. 2016. Am J Med 129 (4): 354 –65.https://doi.org/10.1016/j.amjmed.2015.12.005.Response to the 2nd “Myth-busting” articleInterestingly, on Nov 5, Dr. Spiegel publishedanother “Myths in EM” piece in EM News: “Is hs-cTnT Worth the Downstream Testing?. The piece assesses a new randomized trial of the Roche hs -cTnT...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Authors: Hou C, Zheng B, Wang XG, Zhang B, Shi QP, Chen M Abstract Previous studies have reported that short-term statin loading effectively protects statin-naive patients with mild renal insufficiency from contrast-induced acute kidney injury (CI-AKI). The aim of the present study was to determine whether patients with more advanced chronic kidney disease (CKD) and long-term statin therapy also benefit from high-loading statin pretreatment. A total of 256 consecutive patients with moderate-to-severe CKD receiving long-term statin therapy and undergoing percutaneous coronary intervention (PCI) or coronary artery an...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: Available online 9 November 2018Source: American Heart JournalAuthor(s): Neha J. Pagidipati, Adrian Coles, Kshipra Hemal, Kerry L. Lee, Rowena J. Dolor, Patricia A. Pellikka, Daniel B. Mark, Manesh R. Patel, Sheldon E. Litwin, Melissa A. Daubert, Svati H. Shah, Udo Hoffmann, Pamela S. Douglas, on behalf of the PROMISE InvestigatorsAbstractBackgroundAlthough sex differences exist in the management of acute coronary syndromes, less is known about the management and outcomes of women and men with suspected coronary artery disease (CAD) being evaluated with non-invasive testing (NIT).MethodsWe investigated se...
Source: American Heart Journal - Category: Cardiology Source Type: research
Abstract Our goal was to measure the association of CXCL5 and molecular phenotypes associated with coronary atherosclerosis severity in patients at least 65 years old. CXCL5 is classically defined as a proinflammatory chemokine, but its role in chronic inflammatory diseases, such as coronary atherosclerosis, is not well defined. We enrolled individuals who were at least 65 years old and undergoing diagnostic cardiac catheterization. Coronary artery disease (CAD) severity was quantified in each subject via coronary angiography by calculating a CAD score. Circulating CXCL5 levels were measured from plasma, and both ...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
A 61-year-old hypertensive woman, known for seronegative arthritis under immunosuppressive therapy, was admitted to our department for dyspnea New York Heart Association Class II, angina and a positive stress cardiac-magnetic resonance imaging (MRI) showing an anteroseptal and inferoseptal inducible ischaemia (Panels A: rest andB: stress). Physical examination was unremarkable and laboratory values figured out a mild hypercholesterolaemia. The coronary anatomy at angiography showed a tiny, rudimentary vessel arising from the ostium of the right coronary artery (RCA) and no significant narrowing of the left coronary artery ...
Source: European Heart Journal - Category: Cardiology Source Type: research
AbstractContrast-induced acute kidney injury (CI-AKI) is a common complication of intravascular administration of contrast media used in coronary angiography, percutaneous coronary intervention and other diagnostic and interventional procedures. This review article aims at summarizing the published literature regarding the prevention of CI-AKI, by focusing on available high-quality meta-analyses addressing this matter. Apart from adequate hydration, a number of pharmacologic agents have been proposed as potential candidates to be included in the routine preparation, prior to the patient ’s arrival in the cardiac cath...
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Authors: Saad M, Karam B, Faddoul G, Douaihy YE, Yacoub H, Baydoun H, Boumitri C, Barakat I, Saifan C, El-Charabaty E, Sayegh SE Abstract Patients with chronic kidney disease (CKD) are three times more likely to have myocardial infarction (MI) and suffer from increased morbidity and higher mortality. Traditional and unique risk factors are prevalent and constitute challenges for the standard of care. However, CKD patients have been largely excluded from clinical trials and little evidence is available to guide evidence-based treatment of coronary artery disease in patients with CKD. Our objective was to assess whet...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
Background— The frequency, causes, and impact of myocardial infarction (MI) after successful percutaneous coronary intervention have not been well studied. Methods and Results— The Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents (ADAPT-DES) study was a prospective, multicenter registry study of 8582 patients undergoing successful drug-eluting stent implantation at 11 centers in the United States and Germany. After excluding 128 patients with periprocedural MI, we investigated the pathogenesis, frequency, and long-term consequences of non-periprocedural MI in 8454 patients. MI during 2-year fol...
Source: Circulation: Cardiovascular Interventions - Category: Cardiology Authors: Tags: Myocardial Infarction, Catheter-Based Coronary and Valvular Interventions Cardiac Catheterization Source Type: research
In conclusion, low levels of HDL-cholesterol and high levels TC/HDL-C ratio are strong biological markers of disease occurrence and severity in the Lebanese population.
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
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