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After 10 months, Alnylam still can't explain patient trial deaths

More than 10 months after disclosing that patients who received one of its experimental drugs in a late-stage trial had died at a far higher rate than those on placebo, Cambridge-based Alnylam Pharmaceuticals still cannot conclusively explain what went wrong. Alnylam (Nasdaq: ALNY) on Wednesday released the results of its investigation into the deaths of older patients with heart problems who took revusiran, a potential treatment for a deadly inherited disease called hATTR cardiomyopathy. In October,…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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Takotsubo cardiomyopathy (TCM) is a form of stress-induced cardiomyopathy featured by the dilatation of the apex of the left ventricle during systole. Whereas the pathogenesis of this disorder is not well unde...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Case report Source Type: research
Conclusion: In summary, our study demonstrated the up-regulation of RGC-32 contributed to the imbalance of Treg/Th17 cells in patients with DCM.Cell Physiol Biochem 2017;43:1515 –1525
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Authors: Kalayinia S, Goodarzynejad H, Maleki M, Mahdieh N Abstract The Human Genome Project (HGP), as the primary sequencing of the human genome, lasted more than one decade to be completed using the traditional Sanger's method. At present, next-generation sequencing (NGS) technology could provide the genome sequence data in hours. NGS has also decreased the expense of sequencing; therefore, nowadays it is possible to carry out both whole-genome (WGS) and whole-exome sequencing (WES) for the variations detection in patients with rare genetic diseases as well as complex disorders such as common cardiovascular disea...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
AbstractAims Diabetes is associated with higher arterial stiffness —an early marker of cardiovascular disease. The coupling between arterial stiffness and myocardial function is still unresolved. We investigate associations between arterial stiffness and early myocardial impairment assessed with advanced echocardiography.MethodsIn 305 type 1 diabetes (T1D) patients without known heart disease and with normal left ventricular ejection fraction (LVEF) (biplane LVEF  >  45%), we measured arterial stiffness as pulse wave velocity (PWV) and performed conventional and speckle-tracking echocardiography assess...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Non-compaction cardiomyopathy (NCCM) is characterized by prominent trabeculations, deep intertrabecular recesses, and a thick non-compacted endocardial myocardium. Prevalence in the general population remains ...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Case report Source Type: research
Conclusions Women with prolonged labour do not appear to be at a higher short-term risk of cardiac outcomes. Teaser We assessed the risk of heart failure, cardiomyopathy or dysrhythmia in women with a history of prolonged labour. We conducted a population-based cohort study in the entire province of Ontario, including all singleton livebirths at 24 to 41 weeks’ gestation, between 1992 and 2016. Women with prolonged labour dif not appear to be at a higher future risk of the heart failure, cardiomyopathy or dysrhythmia.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Background: Recent studies have demonstrated that intramyocardial adipose tissue (IMAT) may contribute to ventricular electrophysiological remodeling in patients with chronic myocardial infarction. Using an ovine model of myocardial infarction, we aimed to determine the influence of IMAT on scar tissue identification during endocardial contact mapping and optimal voltage-based mapping criteria for defining IMAT dense regions. Method and Results: In 7 sheep, left ventricular endocardial and transmural mapping was performed 84 weeks (15–111 weeks) post-myocardial infarction. Spearman rank correlation coefficient was u...
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Arrhythmias, Electrophysiology, Animal Models of Human Disease Original Articles Source Type: research
Conclusions: Genomic rearrangements were detected in 7% of AC probands negative for pathogenic point mutations in desmosomal genes, highlighting the potential of CNVs analysis to substantially increase the diagnostic yield of genetic testing. Genotype–phenotype correlation demonstrated the presence of the disease in about one third of family members carrying the CNV, underlying the role of other factors in the development and progression of the disease.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Arrhythmias, Sudden Cardiac Death, Clinical Studies, Genetics, Cardiomyopathy Original Articles Source Type: research
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Arrhythmias, Cardiomyopathy, Electrocardiology (ECG), Magnetic Resonance Imaging (MRI) Correspondence Source Type: research
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Arrhythmias, Computerized Tomography (CT), Imaging, Magnetic Resonance Imaging (MRI) Correspondence Source Type: research
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