After 10 months, Alnylam still can't explain patient trial deaths

More than 10 months after disclosing that patients who received one of its experimental drugs in a late-stage trial had died at a far higher rate than those on placebo, Cambridge-based Alnylam Pharmaceuticals still cannot conclusively explain what went wrong. Alnylam (Nasdaq: ALNY) on Wednesday released the results of its investigation into the deaths of older patients with heart problems who took revusiran, a potential treatment for a deadly inherited disease called hATTR cardiomyopathy. In October,…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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AbstractPurpose of ReviewAtrial fibrillation (AF) and heart failure (HF) are cardiovascular disease epidemics with increasing prevalence worldwide. AF can either be a cause or consequence of cardiomyopathy and HF. Catheter ablation (CA) has been a proven therapy for symptomatic, medically refractory AF patients. The purpose of this review is to highlight the role as well as timing of CA in treating AF patients with HF.Recent FindingsMultiple randomized clinical trials in recent years have elegantly demonstrated the superiority of CA in improving survival, quality of life, ventricular function, and reduce hospitalizations, ...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
Condition:   Ischemic Cardiomyopathy Intervention:   Sponsor:   Yonsei University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Valvular Heart Disease;   Implantable Cardioverter Defibrillator;   Sudden Cardiac Death;   Primary Prevention Intervention:   Device: ICD implantation Sponsors:   Keimyung University Dongsan Medical Center;   Medtronic Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ischemic Cardiomyopathy Intervention:   Sponsor:   Yonsei University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Valvular Heart Disease;   Implantable Cardioverter Defibrillator;   Sudden Cardiac Death;   Primary Prevention Intervention:   Device: ICD implantation Sponsors:   Keimyung University Dongsan Medical Center;   Medtronic Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurpose of reviewThis review summarizes the pathophysiology, peripartum treatment, and anesthetic management of parturients with cardiac disease. Valvular disease, coronary disease, and cardiomyopathy are specifically addressed in the context of the normal physiologic changes of pregnancy. We offer recommendations for anesthetic approaches, hemodynamic goals with an emphasis on interdisciplinary planning between anesthesiologists, cardiologists, cardiothoracic surgeons, obstetricians, maternal fetal medicine specialists, and neonatologists.Recent findingsVaginal delivery with neuraxial analgesia can be well tolerat...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Hypertrophic cardiomyopathy (HC) is a heterogeneous disease with a variable clinical course. Predictors of long-term adverse cardiovascular events are needed. Our objectives were to determine the long term prognostic value of a single and serial point of care (POC) B-type natriuretic-peptide (BNP) measurements in HC. One hundred and eleven ambulatory patients with HC (mean age 53 ±16years) were prospectively recruited over a 2-year period (2004-2006). A clinical assessment, comprehensive echocardiogram, and a POC BNP level was obtained at baseline and at a 1-2 year follow-up.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Transaortic septal myectomy (TSM) is the gold-standard surgery in obstructive hypertrophic cardiomyopathy (HCM) but is not optimal for children under 5 years and with right ventricular outflow tract (RVOT) obstruction. We evaluated outcomes with the modified Konno procedure in children with severe forms of obstructive HCM.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
We describe a 30-year-old female, 6 weeks after delivery and 5 years after bariatric surgery, who was admitted to the cardiology department because of dyspnea and clinical evidence of heart failure, as well as an echocardiogram that demonstrated reduced systolic left ventricular function. Standard antifailure regimen shows mild benefit. Zinc supplements added to treatment lead to significant clinical and echocardiographic improvement. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: International Journal of Angiology - Category: Cardiology Authors: Tags: Case Report Source Type: research
AbstractPrevious studies have detected adenovirus and cytomegalovirus (CMV) in cardiac tissue of patients with myocarditis. Therefore, in this study, we investigated the frequency of these viruses, which may be involved in the development of severe dilated cardiomyopathy (DCM). Myocardial tissue from of 23 cardiac transplant candidates with acute idiopathic DCM below the age of 40 years were analyzed by amplification of adenovirus and CMV DNA and subsequent sequencing. Adenovirus was detected in four (17.4%) and CMV in one (4.3%) of the patients. All controls were negative for the presence of both viruses. Our study shows ...
Source: Archives of Virology - Category: Virology Source Type: research
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