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Nature Index Profile: Michael Sporn: A Legacy of Greater Knowledge

Michael Sporn, MD, emeritus professor of pharmacology and toxicology, and medicine, is featured in Nature Index 2017 for his tremendous impact upon biomedical research and drug development.
Source: News at Dartmouth Medical School - Category: Hospital Management Authors: Tags: In the News Insider cancer faculty Features Home-feature Michael Sporn research Source Type: news

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Conclusion: Risk factors and a more advanced clinical stage of USCC have an impact on poor outcomes despite the use of standard treatment methods, adapted for cervical cancer. The outside-pelvic failures tend to seek effective systemic treatment.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
BOSTON (CBS) – It’s a parent’s worst nightmare, hearing not only that your child has cancer but that she might also lose her eye. That’s exactly what happened to an Andover family and their 3-year-old daughter. But as Dr. Mallika Marshall reports, doctors at Boston Children’s Hospital are using a revolutionary technique to try to save her vision and her life. A little over a year ago Dania Snyder was a typical toddler until her parents noticed something unusual about her right eye. “You could see a little flash of a fleshy piece sort of through her pupil,” explains PJ, Dania’...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local Boston Children's Hospital Cancer Dr. Mallika Marshall Source Type: news
KNOXVILLE, Tenn. - A couple on Dec. 11 filed a complaint in Tennessee federal court seeking damages against Monsanto Co., alleging that it knew that the chemical glyphosate, which is the active ingredient in the herbicide Roundup, could pose "significant risks to human health, including a risk of cancer" yet misrepresented it as safe (Warren Ahrent, et al. v. Monsanto Company, No. 18-65, E.D. Tenn.).
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - Category: Medical Law Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Wednesday Afternoon Lecture Series Published and unpublished studies by investigators in the pharmaceutical industry indicate that a disturbingly high number of academic laboratories' reports nominating potential new cancer-drug targets are either non-reproducible or, if reproducible, are not sufficiently robust to form the basis for drug-discovery efforts. The reasons are likely multifactorial, including the ubiquitous use of " down " assays in cancer biology (e.g. decreased cell proliferation, decreased tumor growth, etc.) that incorporate chemical and genetic perturbants that are prone to cause off-target effe...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
We are thrilled that our recently published article addressing the heritability of  colorectal cancer (CRC) in twins1 has spurred broader discussion about screening practices in families affected by the disease. In an editorial accompanying our article, Sammader and Curtin2 elaborated on the burden of CRC among first-degree relatives of probands and cited additional evidence tha t screening may prove especially effective for individuals with a family history. Matuchansky has now further recapitulated existing literature that suggests that familial risk may be higher for siblings than for parents or children of probands.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Conclusions:Children with EA are exposed to significant amounts of radiation and an increased estimated cumulative cancer mortality risk. Efforts should be made to eliminate superfluous imaging. Objectives: Cases of esophageal carcinoma have been documented in survivors of esophageal atresia (EA). Children with EA undergo considerable amounts of diagnostic imaging and consequent radiation exposure potentially increasing their lifetime cancer mortality risk. This study evaluates the radiological procedures performed on patients with EA and estimates their cumulative radiation exposure and attributable lifetime cancer mo...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
ABSTRACTObjective:Helicobacter pylori infection occurs predominantly in childhood. Host immune response gene polymorphism is reported to affect the susceptibility to H pylori infection and the outcome of H pylori-related gastric cancer. Not all H pylori-infected patients, however, exhibit iron deficiency (ID). The relationship between host genetic polymorphisms and ID mediated by H pylori infection is not well understood.Methods:Subjects (nā€Š=ā€Š644) from the general population of age 10 to 18 years were divided into 2 groups based on serology testing for anti-H pylori IgG: seropositive study group; and seronegative contr...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
Conclusion: Patients with OCSCC who have contralateral lymph node metastasis, tumors with a thickness #x3e;25 mm, angiolymphatic invasion, or locoregional recurrence after surgical treatment have a greater risk of developing distant metastasis.ORL 2017;79:347 –355
Source: ORL - Category: ENT & OMF Source Type: research
Conclusions: In conclusion, this meta-analysis shows that cetuximab- and panitumumab-based chemotherapy have different toxicity profiles in terms of the rate of severe adverse events.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
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