Integrating Morphology and Genetics in the Diagnosis of Cartilage Tumors

Cartilage-forming tumors of bone are a heterogeneous group of tumors with different molecular mechanisms involved. Enchondromas are benign hyaline cartilage –forming tumors of medullary bone caused by mutations in IDH1 or IDH2. Osteochondromas are benign cartilage-capped bony projections at the surface of bone. IDH mutations are also found in dedifferentiated and periosteal chondrosarcoma. A recurrent HEY1-NCOA2 fusion characterizes mesenchymal chon drosarcoma. Molecular changes are increasingly used to improve diagnostic accuracy in chondrosarcomas.
Source: Surgical Pathology Clinics - Category: Pathology Authors: Source Type: research