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Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center

The objective of this study was to examine acromegaly treatment outco...
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Research article Source Type: research

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Gabriel Gomes, from Brazil, suffers from gigantism, caused by a tumour of the pituitary gland. A documentary called Body Bizarre, airing on Thursday, follows the boy's journey.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionThis is the largest single center study characterizing SGHA behavior with SGA and SCA control groups in a cohort of surgically resected pituitary adenomas. SGHA present mostly in young females, and should be closely followed due to their higher likelihood of recurrence and potential of progression to clinical acromegaly. We propose that a complete hormonal staining panel be routinely performed for all pituitary adenomas.
Source: Endocrine - Category: Endocrinology Source Type: research
CONCLUSIONS: Familial isolated pituitary adenomas are more common than it was previously thought, therefore, specific questioning regarding family history should be a part of the workup of all patients with pituitary adenomas. Genetically induced pituitary tumors often have aggressive behavior in terms of tumor expansion and resistance to different treatment options and often involve a multidisciplinary approach that combines endocrine, neurosurgical, and radiological specialists. PMID: 29022641 [PubMed - as supplied by publisher]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
ConclusionIn spite of its relatively straightforward diagnosis, which includes clinical/subclinical hyperthyroidism with or without goiter, increased free thyroxine and nonsuppressed TSH levels, and pituitary mass, the diagnosis of TSH-secreting and cosecreting adenomas was frequently unrecognized and thus much delayed. Serum alpha-subunit levels were high in nearly all patients with TSH-secreting adenomas and useful in excluding other conditions in the differential diagnosis. Proper indication and interpretation of simple laboratory tests should be emphasized in medical education to improve diagnostic accuracy.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Abstract IntroductionAcromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone–secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age‐ and gender‐matched healthy controls. MethodsThe present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age‐ and gender‐matched healthy ind...
Source: Journal of Clinical Ultrasound - Category: Radiology Authors: Tags: RESEARCH ARTICLE Source Type: research
Chiasma has started patient enrolment in Phase III CHIASMA OPTIMAL clinical trial of its product candidate Mycapssa (octreotide capsules) as a maintenance therapy to treat adults with acromegaly.
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news
Authors: Young Lee S, Hee Kim J, Hyun Lee J, Hwy Kim Y, Jin Cha H, Wan Kim S, Ha Paek S, Soo Shin C Abstract Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. The CAB (4...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Classic somatostatin analogues aimed at somatostatin receptor type 2, such as octreotide and lanreotide, represent the mainstay of medical treatment for acromegaly. These agents have the potential to decrease hormone secretion and reduce tumour size. Patients with a germline mutation in the aryl hydrocarbon receptor-interacting protein gene, AIP, develop young-onset acromegaly, poorly responsive to pharmacological therapy. In this review, we summarise the most recent studies on AIP-related pituitary adenomas, paying special attention to the causes of somatostatin resistance; the somatostatin receptor profile including type...
Source: Journal of Endocrinology - Category: Endocrinology Authors: Tags: Review Source Type: research
Abstract Orofacial changes are frequent in acromegaly. Their evolution is slowly progressive. The lips (everted and thickened), the mandibular morphology (prognathism), the tongue (macroglossia), the soft palate and the uvula (increased and thickened), the parodontis (gingival hyperplasia, paradontitis), the teeth (increased interdental spaces, hypercementosis, increased dental mobility, multiple tooth loss) are concerned. Functional consequences are significant (obstructive sleep apnea syndrome, malocclusion, pain of the oral maxillofacial area, decrease of the quality of life). They are rarely noticed as the fir...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
AbstractPurposeThe aim of this study is to investigate guideline application and colonoscopy findings in real-life practice in acromegaly.MethodsWe conducted a retrospective observational non-interventional and cross-sectional analysis on 146 patients with acromegaly (ACRO) referred to our clinic. We evaluated colonoscopy data, focusing on the correlation between colonoscopy findings and hormonal/metabolic values.ResultsThe total number of colonoscopies performed in ACRO patients increased from 6 in the period 1990 –1994 to 57 in the period 2010–2014. Colonoscopy procedures were performed according to guideline...
Source: Pituitary - Category: Endocrinology Source Type: research
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