Four pathways of CD1 antigen presentation to T cells.

Four pathways of CD1 antigen presentation to T cells.
Curr Opin Immunol. 2017 Jul 27;46:127-133
Authors: Moody DB, Cotton RN
Abstract
CD1a, CD1b, CD1c and CD1d proteins migrate through distinct subcellular compartments of antigen presenting cells and so can be considered to take four separate pathways leading to display of lipid antigens to T cell receptors. This review discusses the intersection of CD1 trafficking and lipid antigen loading mechanisms in cells, highlighting key controversies relating to CD1 gene expression, size mismatches between antigens and CD1 binding clefts and unexpected mechanisms of T cell receptor-based recognition.
PMID: 28756303 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - July 27, 2017 Category: Allergy & Immunology Authors: Moody DB, Cotton RN Tags: Curr Opin Immunol Source Type: research