Comparison of effects of zoledronic acid and clodronate on the bone structure: imaginologic and histologic study

The objective of this study was to compare, by means of histologic and imagiologic tools, the bone structure of mandibles of rats treated and not treated with bisphosphonates (BPs). 34 rats were divided in 3 groups: (1) 12 mandibles of rats treated with zoledronic acid; (2) 12 mandibles of rats treated with clodronate; (3) control group, 10 mandibles of rats that received saline solution. All specimens were exposed to cone beam computed tomography (CBCT). The images were analyzed to obtain the bone density (BD) in Hounsfield Units (HU), using the software OsiriX 7.0.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: RP - Research Poster Source Type: research