Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules.

Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules.
Ageing Res Rev. 2017 Jul 20;:
Authors: Gardner JK, Mamotte CDS, Jackaman C, Nelson DJ
Abstract
Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss our current understanding of the influence of aging and cancer on key DC and T cell inhibitory molecules/pathways, the potential underlying cellular and molecular mechanisms contributing to their modulation, and the possibility of therapeutically targeting inhibitory molecules in elderly cancer patients.
PMID: 28736117 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - July 20, 2017 Category: Genetics & Stem Cells Authors: Gardner JK, Mamotte CDS, Jackaman C, Nelson DJ Tags: Ageing Res Rev Source Type: research