Charting the “ Unknown Unknowns ” of Cancer Progression

NCI ’ s Center for Cancer Research (CCR) Grand Rounds Dr. Hani Goodarzi is an assistant professor at the University of California, San Francisco. With a dual expertise in computational and experimental cancer biology, he brings a multidisciplinary approach to studying cancer progression. His research is focused on developing strategies that enable an unbiased search for previously unknown pathways that drive oncogenesis and metastasis. As a postdoctoral fellow, at Columbia University and then at Rockefeller University, he developed several key technologies that led to the discovery of novel drivers of breast cancer metastasis. Chief among them, he led a multi-lab collaborative effort to devise and implement a computational platform named TEISER that systematically identifies cis-regulatory elements in RNA with strong structural features. By applying TEISER to differential RNA stability measurements between poorly and highly metastatic cells, he revealed a new post-transcriptional regulatory pathway that promotes breast cancer metastasis. In addition, by developing novel technologies for genome-wide measurement of hard-to-quantify RNA molecules, he has made key discoveries about the role of tRNAs and tRNA fragments in cancer metastasis. In 2016, he started his lab at UCSF where he continues to expand on his multidisciplinary platform to find new pathways involved in human disease. He also seeks to translate his findings to the clinic by developing therapeutic regimens that t...
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