Nitrophenyl dihydropyridine-derivatives from Seriphidium oliverianum

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Liaquat Ali, Muhammad Imran Tousif, Naheed Riaz, Mamona Nazir, Hidayat Hussain, Nusrat Shafiq, Abdul Jabbar, Rasool Bakhsh Tareen, Muhammad Saleem The chromatographic purification of the n-hexane soluble part of methanolic extract of Seriphidium oliverianum (J. Gay ex Besser) yielded six secondary metabolites that includes two new natural products; diethyl-2,6-diphenyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (1) and 2,6-diacetyl-3,5-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine (2) along with four known phytochemicals; tetradecyl ferulate (3), octadecyl coumarate (4), methyl coumarate (5) and methyl grevillate (6). The new compounds were characterized with the help of 1D-, 2D-NMR and high resolution mass spectrometric techniques, whereas, the known compounds were identified through 1D-NMR and mass spectrometry, and in comparison with the literature values. Compound 1 is synthetically known, however, it is first time reported from any natural source, whereas, compound 2 has never been reported from any other source before. All the isolates were screened in anti-urease and anti-glucosidase bioassay but were found inactive. Graphical abstract

Source: Phytochemistry Letters - July 18, 2017 Category: Chemistry Source Type: research