Tissue specificity of in  vitro drug sensitivity

Conclusion: Our meta-analysis of pan-cancer drug screening datasets indicates that most tested drugs exhibit tissue-specific sensitivities in a large panel of cancer cell lines. However, the observed preclinical results do not translate to the clinical setting. Our results suggest that additional research into showing parallels between preclinical and clinical data is required to increase the translational potential of in  vitro drug screening.
Source: Journal of the American Medical Informatics Association - Category: Information Technology Source Type: research