Drinking alcohol while pregnant could have transgenerational effects

(University of California - Riverside) Soon-to-be mothers have heard the warning - don't drink while pregnant. The Centers for Disease Control and Prevention (CDC) has issued numerous statements about the dangers of alcohol consumption during pregnancy, as it can lead to Fetal Alcohol Spectrum Disorders (FASD) in newborns.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Abstract Fetal alcohol syndrome (FAS) is the most severe condition of fetal alcohol spectrum disorders (FASD) and is associated with congenital heart defects. However, more subtle defects such as ventricular wall thinning and cardiac compliance may be overlooked in FASD. Our studies focus on the role of cardiac fibroblasts in the neonatal heart, and how they are affected by prenatal alcohol exposure (PAE). We hypothesize that PAE affects fibroblast function contributing to dysregulated collagen synthesis, which leads to cardiac dysfunction. To investigate these effects, pregnant C57/BL6 mice were intraperitoneally...
Source: Cardiovascular Toxicology - Category: Cardiology Authors: Tags: Cardiovasc Toxicol Source Type: research
Advances in Dual Diagnosis, Ahead of Print. Purpose Fetal alcohol spectrum disorder (FASD) is an umbrella term for a range of conditions that may occur in an individual whose mother drank alcohol during pregnancy. There has been little research into the experience of birth mothers of children with FASD and no published work of this kind in the UK. This is in contrast to a number of studies that have been conducted on foster/adoptive parents. In light of the recent publication in the UK of a mixed methods study on adoptive carers, it is timely to conduct research on birth mothers in the UK. The purpose of this paper is to e...
Source: Advances in Dual Diagnosis - Category: Psychiatry Source Type: research
CONCLUSION: This FASD model takes advantage of the similarities between humans and rhesus macaques in gestational length relative to brain development, as well as similarities in ethanol self-administration and metabolism. The daily 1.5 g/kg dose of ethanol through the first trimester does not influence pregnancy success rates. However, pregnancy influences drinking behavior during the second month of pregnancy. Future publications using this model will describe the effect of early-gestational ethanol exposure on anatomical and functional brain development at subsequent gestational ages. This article is protected by copyri...
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research
Publication date: Available online 30 November 2018Source: Preventive MedicineAuthor(s): Cheryl McQuire, Raja Mukherjee, Lisa Hurt, Andrea Higgins, Giles Greene, Daniel Farewell, Alison Kemp, Shantini ParanjothyAbstractFetal alcohol spectrum disorders (FASDs) are lifelong disabilities caused by prenatal alcohol exposure. Prenatal alcohol use is common in the UK, but FASD prevalence was unknown. Prevalence estimates are essential for informing FASD prevention, identification and support.We applied novel screening algorithms to existing data to estimate the screening prevalence of FASD. Data were from a population-based coho...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Up to 17 per cent of children could have symptoms consistent with fetal alcohol spectrum disorder (FASD) according to new research published today (Friday 30 November) in Preventative Medicine.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Research; Institutes, ALSPAC; Press Release Source Type: news
ConclusionAccurately assessing prenatal alcohol consumption is challenging in any setting but it is exceptionally challenging when assessed 13 ‐17 years retrospectively as part of a FASD assessment for a young person sentenced to detention. Recording and recoding detailed qualitative responses was required to provide an accurate assessment of PAE using the AUDIT‐C. Standardized recording of PAE in antenatal and birth records would faci litate later assessments for FASD and provide opportunities for advice and support for women who continue to drink during pregnancy.This article is protected by copyright. All rights reserved.
Source: Alcoholism: Clinical and Experimental Research - Category: Addiction Authors: Tags: Original Research Article Source Type: research
CONCLUSION: Accurately assessing prenatal alcohol consumption is challenging in any setting but it is exceptionally challenging when assessed 13-17 years retrospectively as part of a FASD assessment for a young person sentenced to detention. Recording and recoding detailed qualitative responses was required to provide an accurate assessment of PAE using the AUDIT-C. Standardized recording of PAE in antenatal and birth records would facilitate later assessments for FASD and provide opportunities for advice and support for women who continue to drink during pregnancy. This article is protected by copyright. All rights reserv...
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research
ConclusionsER stress plays an important role in ethanol ‐induced damage to the developing brain. Inhibition of ER stress is neuroprotective and may provide a new therapeutic strategy to treat FASD.This article is protected by copyright. All rights reserved.
Source: Alcoholism: Clinical and Experimental Research - Category: Addiction Authors: Tags: Original Research Article Source Type: research
CONCLUSIONS: ER stress plays an important role in ethanol-induced damage to the developing brain. Inhibition of ER stress is neuroprotective and may provide a new therapeutic strategy to treat FASD. This article is protected by copyright. All rights reserved. PMID: 30403409 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research
From the latestNIAAA Director's Blog:Fetal alcohol spectrum disorders, also known as FASD, is a term that refers to the broad range of lifelong birth defects and neurodevelopmental abnormalities that occur as a result of prenatal alcohol exposure. In this edition of my blog, I want to remind everyone that there is no known safe level of alcohol, or time to drink, during pregnancy.  Read more...
Source: NIAAA News - Category: Addiction Authors: Source Type: news
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