Dartmouth Researchers Find that Mothers ’ Antibodies Against HSV-1 Can Protect Their Infants from the Virus

A team of Dartmouth researchers has found that mothers who have developed antibodies against the herpes simplex virus (HSV-1) can pass these antibodies to the nervous systems of their infants, protecting them from acquiring the virus.
Source: News at Dartmouth Medical School - Category: Hospital Management Authors: Tags: News David Leib Features Home-feature HSV-1 infant health infectious diseases pediatrics research virus Source Type: news

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Tetracycline-responsive transcriptional activator driven by the liver-specific mouse albumin promoter (Alb-tTA).TheE. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that was inhibited by tetracycline. The transcription activator was a fused protein consisting of a tetracycline repressor gene (tetR) that was only active in the presence of tetracycline and a herpes simplex virus protein (VP-16) transcription activating domain. Transcription was induced only in the absence of tetracycline (Tet-Off). A liver-specific promoter such as mouse albumin determined tha...
Source: NIDDK Research Materials - Category: Research Source Type: research
e;n Boglárka Csupor-Löffler Judit Hohmann Andrea Vasas Juncaceae species are rich sources of phenanthrenes. The present study has focused on the isolation and structure determination of biologically active components from Juncus compressus. Eleven compounds (nine phenanthrenes and two flavonoids) have been isolated from the plant by the combination of different chromatographic methods. Two compounds (compressins A (Compound 1) and B (Compound 2)) are novel natural products, while seven phenanthrenes (effusol (Compound 3), effususol (Compound 4), juncusol (Compound 5), 2-hydroxy-1-methyl-4-oxymethylene...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
This article reviews these infections based on their underlying etiology: bacterial, fungal, and viral causes. This article discusses the etiology, presentation, evaluation, and management of impetigo, bullous impetigo, erysipelas, cellulitis, periorbital cellulitis, orbital cellulitis, folliculitis, furuncles, carbuncles, abscess, necrotizing fasciitis, sporotrichosis, tinea corporis, tinea pedis, tinea capitis, Herpes Simplex Virus, zoster, molluscum contagiosum, and warts. PMID: 30115333 [PubMed - in process]
Source: Primary Care - Category: Primary Care Authors: Tags: Prim Care Source Type: research
HSV is the most common identified cause of severe and fatal infectious encephalitis, accounting for approximately 10 –20% of all viral encephalitis cases in the United States [1]. The incidence of neonatal HSV infection is similar to that of serious bacterial infection amongst young infants evaluated for sepsis [2]. Despite antiviral therapy, the morbidity and mortality of HSVE remains unacceptably high; up to 6 9% of neonates and 44-62% of children and adults will suffer long-term neurological impairment [3,4].
Source: Journal of Clinical Virology - Category: Virology Authors: Source Type: research
Tetracycline-responsive transcriptional activator driven by the liver-specific mouse major urinary protein promoter (MUP-tTA).TheE. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that was inhibited by tetracycline. The transcription activator was a fused protein consisting of a tetracycline repressor gene (tetR) that was only active in the presence of tetracycline and a herpes simplex virus protein (VP-16) transcription activating domain (Tet-Off). Transcription was induced only in the absence of tetracycline (Tet-Off). A liver-specific promoter such as the ...
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Tetsuro Ito, Kyoko Hayashi, Masataka Nishiguchi, Toshimitsu Hayashi, Munekazu IinumaAbstractA new resveratrol dimer C-glucoside [uliginosides D (1)] was isolated from the stem bark of Shorea uliginosa, along with 21 resveratrol derivatives (2–22). Eight of these compounds (1, 3–9) comprised the building block, 4-C-glucosylresveratrol (10). The absolute configurations of six compounds (1 and 3–7) were determined using NMR and circular dichroism. The antiviral effects of the main oligostilbenoid compounds in this plant and re...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
occi Lucia Nencioni DR2B and DR2C extracts, obtained by ethanolic maceration of peel from commercially and physiologically ripe aubergine berries, were studied for the antioxidative cytoprotective properties and anti-HSV-1 activity, in line with the evidence that several antioxidants can impair viral replication by maintaining reducing conditions in host cells. The antioxidative cytoprotective effects against tBOOH-induced damage were assessed in Caco2 cells, while antiviral activity was studied in Vero cells; polyphenolic fingerprints were characterized by integrated phytochemical methods. Results highlighted differ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusions: The prognosis of SSNHL in children is closely related to the type of audiometric curve and the onset of treatment. Intratympanic methylprednisolone and compound betamethasone injected postauricularly could be effective for SSNHL in children.
Source: Otology and Neurotology - Category: ENT & OMF Tags: Pediatric Otology Source Type: research
A 23-day-old term neonate was admitted with fever and seizure for 1 day. On examination, he was febrile and irritable. He also showed a bulging fontanel, nuchal rigidity, and the absence of skin lesions. Infection of the central nervous system was suspected. Examination of cerebrospinal fluid (CSF) revealed a nuclear cell count of 360  × 106/l, with 76% of mononuclear cells, and a protein content of 1062 mg/l. PCR results of herpes simplex virus 2 (HSV II) DNA in both serum and CSF were positive.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Images Source Type: research
CONCLUSION: Extensive studies for the presence of HSV by PCR of the placenta and infant failed to detect the virus. PMID: 30103879 [PubMed - in process]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
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