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Dartmouth Researchers Find that Mothers ’ Antibodies Against HSV-1 Can Protect Their Infants from the Virus

A team of Dartmouth researchers has found that mothers who have developed antibodies against the herpes simplex virus (HSV-1) can pass these antibodies to the nervous systems of their infants, protecting them from acquiring the virus.
Source: News at Dartmouth Medical School - Category: Hospital Management Authors: Tags: News David Leib Features Home-feature HSV-1 infant health infectious diseases pediatrics research virus Source Type: news

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ningham Herpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Therefore, HSV-1 has adapted mechanisms to promote its survival by exploiting the microtubule and actin cytoskeletons to direct its active transport, infection, and spread between neurons and epithelial cells during primary and recurrent infections. This review will focus on the currently known mechanisms utilized by HSV...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
In this study, C. nutans crude extract was tested for antiviral activities against CyHV‐3 in koi carp. Results showed effective antiviral activity against CyHV‐3 pre‐ and post‐infection. The 50% lethal concentration (LC50) of extract was higher than 5 mg/ml. The 50% effective dose (ED50) was 0.99 mg/ml, 0.78 mg/ml, 0.75 mg/ml and 0.71 mg/ml at 1, 2, 3 and 4 hr pre‐infection, respectively. The ED50 from post‐infection tests was 2.05 mg/ml and 2.34 mg/ml at 0 and 24 hr, respectively. These results demonstrated that crude extract expressed antiviral activity a...
Source: Journal of Fish Diseases - Category: Zoology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionSibling visits to the NICU did not result in an increase in the nosocomial viral infection rate.
Source: Pediatrics International - Category: Pediatrics Authors: Tags: Original Article Source Type: research
Conclusion Due to the frequent delay in HSV diagnosis and the safety of Acyclovir, we recommend empirically administering Acyclovir in patients suspected of HSV hepatitis.
Source: IDCases - Category: Infectious Diseases Source Type: research
ConclusionsWhilst various pathological processes have been implicated in the development of indeterminate hepatitis, the specific cause remains elusive. There is an urgent need for general consensus on a specific definition and exclusion of confounding aetiologies with coordinated multicentre investigation of this rare condition to identify aetiology and develop therapies to reduce the significant mortality and need for emergency liver transplantation associated with this condition.
Source: Alimentary Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: SYSTEMATIC REVIEW Source Type: research
Publication date: Available online 19 February 2018 Source:Multiple Sclerosis and Related Disorders Author(s): Jie Li, Yan Xu, Haitao Ren, Yicheng Zhu, Bin Peng, Liying Cui Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune disease. This is the first report of a case of autoimmune GFAP astrocytopathy after herpes simplex viral encephalitis (HSVE). A 35-year-old female patient presented with a combination of headache, fever, seizure and psychiatric/behavioral abnormalities. She had GFAP-IgG in both serum and cerebrospinal fluid (CSF). Magnetic resonance imaging (MRI) with gadolinium-enha...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Authors: Shiraki K Abstract Valacyclovir and famciclovir enabled successful systemic therapy for treating herpes simplex virus (HSV) and varicella zoster virus (VZV) infection by their phosphorylation with viral thymidine kinase. Helicase-primase inhibitors (HPIs) inhibit the progression of the replication fork, an initial step in DNA synthesis to separate the double strand into two single strands. The HPIs amenamevir and pritelivir have a novel mechanism of action, once-daily administration with nonrenal excretory characteristics, and clinical efficacy for genital herpes. Amenamevir exhibits anti-VZV and anti-HSV ...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
Publication date: Available online 17 February 2018 Source:Journal of the Chinese Medical Association Author(s): Yiu-Tai Li, Peng-Hui Wang
Source: Journal of the Chinese Medical Association - Category: General Medicine Source Type: research
ConclusionWe have developed a powerful animal model to advance the current selection of effective treatments for patients with advanced prostate cancer.
Source: The Prostate - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: McQuillan G, Kruszon-Moran D, Flagg EW, Paulose-Ram R Abstract During 2015-2016, prevalence of herpes simplex virus type 1 (HSV-1) was 47.8%, and prevalence of herpes simplex virus type 2 (HSV-2) was 11.9%. Prevalence of both HSV-1 and HSV-2 increased with age. Prevalence of both HSV-1 and HSV-2 was higher among females than males. Prevalence of HSV-1 was highest among Mexican- American persons and lowest among non-Hispanic white persons. HSV-2 prevalence was highest among non-Hispanic black persons and lowest among non-Hispanic Asian persons. Prevalence of both HSV-1 and HSV-2 decreased from 1999-2000 to ...
Source: NCHS data brief - Category: American Health Tags: NCHS Data Brief Source Type: research
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