Driving to Cancer on a Four-Lane Expressway.

Driving to Cancer on a Four-Lane Expressway.
Trends Genet. 2017 Jun 28;:
Authors: Galluzzi L, Vitale I
Abstract
Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. This paves an expressway to extensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.
PMID: 28668385 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - June 28, 2017 Category: Genetics & Stem Cells Authors: Galluzzi L, Vitale I Tags: Trends Genet Source Type: research