c-MYC mRNA tail tale about glutamine control of transcription

Dejure et al (2017) demonstrates an intriguing link between glutamine, c-MYC protein levels, and c-MYC-dependent transcription. Glutamine-dependent c-MYC protein level, which is sensed through the c-MYC mRNA 3'-UTR, determines global transcriptional response to glutamine deprivation in HCT116 colon cancer cells. These findings add another layer of complexity to c-MYC's role as a nexus in metabolic regulation.

Source: EMBO Journal - July 3, 2017 Category: Molecular Biology Authors: Dang, C. V. Tags: Cancer, Metabolism, Transcription News [amp ] Views Source Type: research