Proteasome Subunit Beta Type 1 P11A polymorphism is a new prognostic marker in multiple myeloma

We retrospectively analyzed the prognostic impact of Proteasome subunit beta type 1 rs12717 polymorphism in 211 consecutively diagnosed multiple myeloma cases. Patients carrying the variant G allele showed significantly shorter progression free survival. In proteasomes of individuals with G/G genotype we found significantly reduced protease activity and lower inhibitory capacity of bortezomib on the caspase- and trypsin-like activity.

Source: Clinical Lymphoma, Myeloma and Leukemia - June 30, 2017 Category: Hematology Authors: Gergely Varga, G ábor Mikala, Katalin Piroska Kiss, Éva Kosóczki, Edit Szabó, Nóra Meggyesi, Katalin Balassa, Petra Kövy, Bálint Tegze, Gergely Szombath, Attila Tordai, Hajnalka Andrikovics, László Homolya, Tamás Masszi Tags: Original Study Source Type: research