Effect of electronic and steric properties of 8-substituted quinolines in gold(III) complexes: Synthesis, electrochemistry, stability, interactions and antiproliferative studies.

Effect of electronic and steric properties of 8-substituted quinolines in gold(III) complexes: Synthesis, electrochemistry, stability, interactions and antiproliferative studies.
J Inorg Biochem. 2017 Jun 17;174:111-118
Authors: Casado-Sánchez A, Martín-Santos C, Padrón JM, Mas-Ballesté R, Navarro-Ranninger C, Alemán J, Cabrera S
Abstract
In this work the synthesis and characterization of new gold(III) complexes with quinoline ligands are described. These complexes contain different steric and electronic properties of the donor atom at 8-position of the quinoline in order to modulate their stability and their biological activity. Their redox potential, stability in organic and aqueous solvents, and their biological activity in a panel of six different human tumor cell lines are also presented. In addition, interaction studies of the complexes with model biological molecules (pBR322 and L-acetyl-N-cysteine) were carried out, suggesting that their main target are proteins. From these studies, we have found that the gold(III) complex with an N-tosyl-8-aminoquinoline ligand is the most active complex in all the tumor cell lines, including the cisplatin resistant T-47D and WiDr cell lines. Moreover, this complex showed to be the most stable compound in DMSO and saline solution, even after several hours.
PMID: 28662405 [PubMed - as supplied by publisher]

Source: Journal of Inorganic Biochemistry - June 17, 2017 Category: Biochemistry Authors: Casado-Sánchez A, Martín-Santos C, Padrón JM, Mas-Ballesté R, Navarro-Ranninger C, Alemán J, Cabrera S Tags: J Inorg Biochem Source Type: research