The effect of artesunate on short-term memory in Lyme borreliosis

Lyme borreliosis is associated with memory deficits. While this may be related to cerebral infection by Borrelia bacteria, it may also be caused by concomitant co-infection by Babesia protozoa. The anti-malarial artemisinin-derivative artesunate has been shown to be effective against a number of Babesia species and to have efficacy against human cerebral malaria. We hypothesised that concomitant administration of artesunate in Lyme borreliosis patients would help alleviate the severity of self-reported short-term memory impairment.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research

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In this study, we show upregulation of PfGCN5 upon nutrient stress condition. With the help of chromatin immunoprecipitation coupled high-throughput sequencing (ChIP-seq) and transcriptomic (RNA-sequencing) analyses, we show that PfGCN5 is associated with the genes that are important for the maintenance of parasite cellular homeostasis upon nutrient stress condition. Furthermore, we identified various metabolic enzymes as interacting partners of PfGCN5 by immunoprecipitation coupled with mass spectroscopy, possibly acting as a sensor of nutrient conditions in the environment. We also demonstrated that PfGCN5 interacts and ...
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
Authors: Bouchaud O, Bruneel F, Caumes E, Houzé S, Imbert P, Pradines B, Rapp C, Strady C PMID: 31964565 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Publication date: 25–31 January 2020Source: The Lancet, Volume 395, Issue 10220Author(s): Peter Gething, Simon Hay, Daniel Weiss
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 25–31 January 2020Source: The Lancet, Volume 395, Issue 10220Author(s): Freya J I Fowkes, Eliza Davidson, Kerryn A Moore, Rose McGready, Julie A Simpson
Source: The Lancet - Category: General Medicine Source Type: research
(American Association for the Advancement of Science) A team of nine researchers based in the United States and Burkina Faso will receive the 2019 Newcomb Cleveland Prize, presented by the American Association for the Advancement of Science, for the development of a promising tool in the global fight against malaria and other diseases transmitted by mosquitoes, including dengue and Zika.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(The Wistar Institute) In a study by Wistar and collaborators, a rare, African-specific variant of the TP53 gene called P47S causes iron accumulation in macrophages and other cell types and is associated with poorer response to bacterial infections, along with markers of iron overload in African Americans. Macrophage iron accumulation disrupts their function, resulting in more severe bacterial infections.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
(University of Maryland) The American Association for the Advancement of Science (AAAS) awarded its 2019 Newcomb Cleveland Prize to University of Maryland entomologists Raymond St. Leger, Brian Lovett and their seven West African collaborators for their study describing the development and testing of a genetically engineered fungus to fight mosquito-borne diseases such as malaria, dengue&Zika.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: February 2020Source: The Lancet Global Health, Volume 8, Issue 2Author(s): Jeremy D Keenan, Ahmed M Arzika, Ramatou Maliki, Sanoussi Elh Adamou, Fatima Ibrahim, Mariama Kiemago, Nana Fatima Galo, Elodie Lebas, Catherine Cook, Benjamin Vanderschelden, Robin L Bailey, Sheila K West, Travis C Porco, Thomas M Lietman, Paul M Emerson, Jerusha Weaver, Sheila K West, Robin L Bailey, John Hart, Amza AbdouSummaryBackgroundThe Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) trial found that biannual mass distribution of azithromycin to children younger tha...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Coendemicity between the human immunodeficiency virus (HIV) and Plasmodium parasites, the causative agents of acquired immunodeficiency syndrome (AIDS) and malaria, respectively, occurs in several regions around the world. Although the impact of the interaction between these two organisms is not well understood, it is thought that the outcome of either disease may be negatively influenced by coinfection. Therefore, it is important to understand how current first-line antiretroviral therapies (ART) might impact Plasmodium infection in these regions. Here, we describe the effect of 18 antiretroviral compounds and of first-li...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Mepron, a thick liquid antimicrobial drug used to treat Babesia and malaria, as well as a fungal infection called Pneumocystitis carinii. In 2011, the United Kingdom stopped requiring that dogs brought into the country be inspected for ticks. Earlier this year, several dogs tested positive for babesia, a malaria-like disease transmitted to ticks that previously had only been found in foreign. These dogs had never left the U.K. While babesiosis is a new worry to U.K. dog owners, it's been a threat to human beings for years -- it just hasn't become a health-scare-of-the-week like Zika, West Nile, avian and swine flu. Most...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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